School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 3/F, Laboratory Block, 21 Sassoon Road, Hong Kong SAR, China.
Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
J Immunol Res. 2021 May 17;2021:5531220. doi: 10.1155/2021/5531220. eCollection 2021.
The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的核衣壳蛋白（NP）含有免疫原性表位，可诱导针对病毒感染的细胞毒性 T 淋巴细胞（CTL）。这使得核衣壳蛋白成为开发针对 SARS-CoV-2 感染的疫苗的合适候选物。本文报告了使用可溶解的微针贴片皮内递呈 NP 抗原，可诱导显著的 B 细胞和 T 细胞反应。
