环状 RNA 在心血管疾病中的作用：表达、机制与临床前景。
Circular RNA in cardiovascular disease: Expression, mechanisms and clinical prospects.
机构信息
Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
出版信息
J Cell Mol Med. 2021 Feb;25(4):1817-1824. doi: 10.1111/jcmm.16203. Epub 2020 Dec 22.
Abstract
Circular RNAs (circRNAs) are a group of covalently closed, endogenous, non-coding RNAs, which exist widely in human tissues including the heart. Increasing evidence has shown that cardiac circRNAs play crucial regulatory roles in cardiovascular diseases (CVDs). In this review, we aimed to provide a systemic understanding of circRNAs with a special emphasis on the cardiovascular system. We have summarized the current research on the classification, biogenesis and properties of circRNAs as well as their participation in the pathogenesis of CVDs. CircRNAs are conserved, stable and have specific spatiotemporal expression; thus, they have been accepted as a potential diagnostic marker or an incremental prognostic biomarker for CVDs.
摘要
环状 RNA（circRNAs）是一类共价闭合的、内源性的、非编码 RNA，广泛存在于包括心脏在内的人体组织中。越来越多的证据表明，心脏环状 RNA 在心血管疾病（CVDs）中发挥着关键的调节作用。在这篇综述中，我们旨在提供对环状 RNA 的系统理解，特别强调心血管系统。我们总结了目前关于环状 RNA 的分类、生物发生和特性以及它们在 CVD 发病机制中的参与的研究。环状 RNA 具有保守性、稳定性和特定的时空表达，因此被认为是 CVD 的潜在诊断标志物或预后生物标志物。
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