Grochowski Daniel M, Locatelli Marcello, Granica Sebastian, Cacciagrano Francesco, Tomczyk Michał
Dept. of Pharmacognosy, Faculty of Pharmacy with the Div. of Laboratory Medicine, Medical Univ. of Białystok, Białystok, Poland.
Dept. of Pharmacy, Univ. "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
Compr Rev Food Sci Food Saf. 2018 Sep;17(5):1395-1421. doi: 10.1111/1541-4337.12389. Epub 2018 Aug 17.
Among flavonoid derivatives, tiliroside is a flavonoid contained in several edible plants or specific plant parts (fruits, leaves, or roots). These parts are often widely used as both food and medicines, in the treatment of various ailments and, in some cases, as food supplements. Considering the easy access to many publications concerning tiliroside and the lack of a review that summarizes the current progress in studies on its safety, efficacy, and presence in the plant kingdom, we present here a review paper on tiliroside and its principal derivatives. The paper also highlights the basic knowledge regarding this molecule, its derivatives, and the analytical approaches used for extraction and quantification, as well as reports on the biological activities against different key enzymes linked to various human diseases. The reported information is also devoted to highlighting the concept "learn from nature to discover new products," particularly in the development of new drugs, food supplements, and nutraceuticals, starting from a natural lead compound such as tiliroside and improving its biological activities (and selectivities) against a specific target for therapeutic purposes.
在黄酮类衍生物中，椴苷是一种存在于多种可食用植物或特定植物部位（果实、叶子或根部）的黄酮类化合物。这些部位常被广泛用作食品和药物，用于治疗各种疾病，在某些情况下还用作食品补充剂。鉴于有许多关于椴苷的出版物且缺乏对其安全性、功效以及在植物界中存在情况的研究进展进行总结的综述，我们在此呈现一篇关于椴苷及其主要衍生物的综述文章。该论文还重点介绍了关于这种分子、其衍生物以及用于提取和定量的分析方法的基础知识，以及针对与各种人类疾病相关的不同关键酶的生物活性报告。所报告的信息还致力于突出“向自然学习以发现新产品”这一概念，特别是在新药、食品补充剂和营养保健品的开发中，从诸如椴苷这样的天然先导化合物出发，为治疗目的改善其针对特定靶点的生物活性（和选择性）。
