The Discovery of Potential Repellent Compounds for (Coquillett) from Six Non-Favored Hosts.

(Coquillett) () is a global extremely invasive quarantine pest which has a wide host range of fruits and vegetables. At present, there are a few control measures for , and deltamethrin and avermectin are commonly used. Among the hosts of , , , , var. , , and are non-favored hosts. However, it is still not clear why these hosts are non-favored and whether there are any repellent components of in these hosts. In this study, the components of these six hosts were collected from the literature, and the genes of odor and chemical sensation were determined from the genome of . After the potential relationships between these components and genes were determined by molecular docking methods, the KEGG and GO enrichment analysis of these genes was conducted, and a complex network of genes vs. components vs. Kegg pathway vs. GO terms was constructed and used to select the key components for experiments. The results show that oleanolic acid (1 mg/mL, 0.1 mg/mL, and 0.01 mg/mL), rotenone (1 mg/mL, 0.1 mg/mL, and 0.01 mg/mL), and beta-caryophyllene oxide (1 mg/mL, 0.1 mg/mL, and 0.01 mg/mL) had a significant repellent effect on , and three components, rotenone (1 mg/mL and 0.1 mg/mL), echinocystic acid (1 mg/mL, 0.1 mg/mL, and 0.01 mg/mL), and beta-caryophyllene oxide (1 mg/mL, and 0.1 mg/mL) had significant stomach toxicity in . Furthermore, a complex signaling pathway was built and used to predict the effect of these components on . These components probably play roles in the neuroactive ligand-receptor interaction (ko04080) and calcium signaling (ko04020) pathways. This study provides a reference for the prevention and control of and a scientific reference for the rapid screening and development of new pest control drugs.