Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
J Korean Med Sci. 2020 Dec 21;35(49):e406. doi: 10.3346/jkms.2020.35.e406.
Menarcheal age has been decreasing worldwide. However, few recent studies have observed trends in menarcheal age in larger populations, and the cutoff age for early menarche remains unclear. Therefore, we aimed to analyze recent trends of menarcheal age and to determine the cutoff age of early menarche based on nationally representative data.
We conducted a cross-sectional study of 351,006 Korean girls aged 12-18 years who were born in 1988-2003 based on the data of the 2006-2015 Korea Youth Risk Behavior Survey. We identified the distribution of age at menarche using the complex sample Cox regression model. Trends in the prevalence of early menarche were determined using the complex sample linear model.
Ninety-five percent of all the participants reported they had experienced menarche. The mean menarcheal age was 13.0 years (95% confidence intervals [CIs], 12.92-13.04) for girls born in 1988 and decreased to 12.6 years (95% CI, 12.54-12.61) for girls born in 2003. The cutoff age (the 3rd percentile value) for early menarche was 10.5 years during the study period. The prevalence of early menarche significantly increased from 1.8% in 2006 to 3.2% in 2015 (-for-trend < 0.001). Downward trends of menarcheal age were noted across all body mass index groups, and this trend was most prominent in the obese group.
We reported an ongoing downward trend in menarcheal age in Korean girls born in 1988-2003, decreasing by 0.4 years over the 15 years.
全球范围内,初潮年龄一直在下降。然而,最近很少有研究观察到较大人群中初潮年龄的趋势,并且早期初潮的截止年龄仍不清楚。因此,我们旨在分析最近初潮年龄的趋势,并根据全国代表性数据确定早期初潮的截止年龄。
我们基于 2006-2015 年韩国青少年风险行为调查的数据,对 1988-2003 年出生的 351006 名 12-18 岁的韩国女孩进行了一项横断面研究。我们使用复杂样本 Cox 回归模型确定初潮年龄的分布。使用复杂样本线性模型确定早期初潮的流行趋势。
所有参与者中有 95%报告说他们经历过初潮。1988 年出生的女孩平均初潮年龄为 13.0 岁(95%置信区间[CI],12.92-13.04),而 2003 年出生的女孩降至 12.6 岁(95%CI,12.54-12.61)。研究期间,早期初潮的截止年龄(第 3 个百分位数值)为 10.5 岁。从 2006 年的 1.8%到 2015 年的 3.2%,早期初潮的患病率显著增加(趋势<0.001)。在所有体重指数组中,初潮年龄都呈下降趋势,在肥胖组中这种趋势最为明显。
我们报告了 1988-2003 年出生的韩国女孩初潮年龄持续下降,在 15 年内下降了 0.4 岁。