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食盐摄入习惯对妊娠期碘营养状况和甲状腺功能的影响。

The effects of salt consumption habits on iodine status and thyroid functions during pregnancy.

机构信息

Department of Endocrinology and Metabolism, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey

Department of Endocrinology and Metabolism, Ministry of Health Yozgat City Hospital, Yozgat, Turkey

出版信息

Turk J Med Sci. 2021 Apr 30;51(2):766-771. doi: 10.3906/sag-2007-127.

Abstract

BACKGROUND/AIM: Iodine is the basic substrate for thyroid hormone synthesis and is vital for the general population and especially pregnant women. Iodine deficiency may cause severe health problems for a foetus. This study aimed to determine the relationship, if any, between iodine level and thyroid function tests, and to determine the relationship between consumption of salt types and its effects on thyroid function tests in the first trimester of pregnancy.

MATERIALS AND METHODS

Three hundred and six pregnant women in the first trimester of pregnancy, who had known no thyroid disease history and had not received iodine supportive therapy, were included in the study. All patients were questioned for their preferred table salt or rock salt in daily use and urine iodine concentrations (UICs) were analysed in spot urine. The results were evaluated statistically according to salt usage preferences.

RESULTS

The median age of patients in the study was 27.8 (± 5.4). In terms of salt consumption habits, 235 (76.8%) of patients reported using table salt, and 71 (23.2%) reported using rock salt. Iodine deficiency was found in 75.81% (n = 232) of all cases according to urinalysis. Median UICs of table salt group were significantly higher than rock salt group (123.7 μg/L and 70.9 μg/L respectively, P < 0.001).

CONCLUSION

Although large-scale salt iodination began long time ago, iodine deficiency is still a serious health problem among pregnant women. According to this study, use of rock salt is associated with low urinary iodine concentration in pregnant women and TSH values within the reference limits are not a good indicator for determining the iodine level.

摘要

背景/目的:碘是甲状腺激素合成的基本底物,对普通人群,尤其是孕妇至关重要。碘缺乏可能会对胎儿造成严重的健康问题。本研究旨在确定碘水平与甲状腺功能测试之间的任何关系,并确定妊娠早期盐的类型及其对甲状腺功能测试的影响之间的关系。

材料和方法

本研究纳入了 306 名已知无甲状腺疾病史且未接受碘支持治疗的妊娠早期孕妇。所有患者均被询问其日常使用的精盐或岩盐偏好,并分析了其随机尿液碘浓度(UIC)。根据盐的使用偏好对结果进行了统计评估。

结果

研究中患者的中位年龄为 27.8(±5.4)岁。在盐的消费习惯方面,235 名(76.8%)患者报告使用精盐,71 名(23.2%)患者报告使用岩盐。根据尿液分析,所有病例中碘缺乏的比例为 75.81%(n=232)。精盐组的 UIC 中位数明显高于岩盐组(分别为 123.7μg/L 和 70.9μg/L,P<0.001)。

结论

尽管大规模的食盐碘化已经进行了很长时间,但碘缺乏仍然是孕妇面临的严重健康问题。根据本研究,岩盐的使用与孕妇尿碘浓度低有关,且参考范围内的 TSH 值并不能很好地指示碘水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d40a/8203153/54c6d21d4902/turkjmedsci-51-766-fig001.jpg

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