Suppr超能文献

用于食品生产动物的基于生理学的药代动力学模型的生理学参数值。第三部分:绵羊和山羊。

Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part III: Sheep and goat.

机构信息

Institute of Computational Comparative Medicine (ICCM), Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.

Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.

出版信息

J Vet Pharmacol Ther. 2021 Jul;44(4):456-477. doi: 10.1111/jvp.12938. Epub 2020 Dec 22.

Abstract

This report is the third in a series of studies that aimed to compile physiological parameters related to develop physiologically based pharmacokinetic (PBPK) models for drugs and environmental chemicals in food-producing animals including swine and cattle (Part I), chickens and turkeys (Part II), and finally sheep and goats (the focus of this manuscript). Literature searches were conducted in multiple databases (PubMed, Google Scholar, ScienceDirect, and ProQuest), with data on relevant parameters including body weight, relative organ weight (% of body weight), cardiac output, relative organ blood flow (% of cardiac output), residual blood volume (% of organ weight), and hematocrit reviewed and statistically summarized. The mean and standard deviation of each parameter are presented in tables. Equations describing the growth curves of sheep and goats are presented in figures. When data are sufficient, parameter values are reported for different ages or production classes of sheep, including fetal sheep, lambs, and market-age sheep (mature sheep). These data provide a reference database for developing standardized PBPK models to predict drug withdrawal intervals in sheep and goats, and also provide a basis for extrapolating PBPK models from major species such as cattle to minor species such as sheep and goats.

摘要

本报告是一系列研究的第三部分,旨在为包括猪和牛(第一部分)、鸡和火鸡(第二部分)在内的食品生产动物以及绵羊和山羊(本文重点)体内药物和环境化学物质的基于生理学的药代动力学(PBPK)模型编译相关生理参数。文献检索在多个数据库(PubMed、Google Scholar、ScienceDirect 和 ProQuest)中进行,对包括体重、相对器官重量(占体重的百分比)、心输出量、相对器官血流量(占心输出量的百分比)、残留血容量(占器官重量的百分比)和红细胞压积等相关参数进行了审查和统计总结。每个参数的平均值和标准差都列在表格中。描述绵羊和山羊生长曲线的方程列在图中。当数据充足时,报告了不同年龄或生产阶段绵羊(包括胎儿绵羊、羔羊和市场年龄绵羊(成熟绵羊))的参数值。这些数据为开发用于预测绵羊和山羊中药物停药间隔的标准化 PBPK 模型提供了参考数据库,也为从牛等主要物种外推 PBPK 模型到绵羊和山羊等小物种提供了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fac0/8359294/fbecaf743de1/JVP-44-456-g004.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验