Division of Nutrition, Physical Activity, and Obesity, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Department of Pediatrics and Penn State College of Medicine, Hershey, PA, USA.
Child Obes. 2021 Jan;17(1):51-57. doi: 10.1089/chi.2020.0192. Epub 2020 Dec 22.
The beginning of postinfancy increase in BMI has been termed the adiposity rebound, and an early rebound increases the risk for obesity in adolescence and adulthood. We examined whether the relation of the age at BMI rebound (age) to subsequent BMI is independent of childhood BMI. From the electronic health records of 2.8 million children, we selected 17,077 children examined at least once each year between ages 2 and <8 years, and who were reexamined between age 10 and <16 years. The mean age at the last visit was 12 years (SD = 1). We identified age for each child using lowess, a smoothing technique. Children who had an age <3 years were, on average, 6.8 kg/m heavier after age 10 years than were children with an age >7 years. However, BMI after age 10 years was more strongly associated with BMI at the rebound (BMI) than with age ( = 0.63 vs. -0.49). Although the relation of age to BMI at the last visit was mostly independent of the BMI, adjustment for age-5 BMI reduced the association's magnitude by about 55%. Both age and the BMI are independently related to BMI and obesity after age 10 years. However, a child's BMI and at ages 5 and 7 years accounts for more of the variability in BMI levels after age 10 years than does age.
婴儿后期 BMI 增长的开始被称为肥胖反弹，早期反弹会增加青少年和成年肥胖的风险。我们研究了 BMI 反弹年龄（年龄）与随后 BMI 之间的关系是否独立于儿童 BMI。从 280 万名儿童的电子健康记录中，我们选择了至少每年检查一次 2 至<8 岁之间且在 10 至<16 岁之间重新检查的 17077 名儿童。最后一次就诊的平均年龄为 12 岁（标准差= 1）。我们使用平滑技术 lowess 为每个孩子确定年龄。年龄<3 岁的儿童在 10 岁后比年龄>7 岁的儿童平均重 6.8kg/m。然而，10 岁以后的 BMI 与反弹时的 BMI（BMI）比与年龄（= 0.63 比-0.49）更密切相关。尽管年龄与最后一次就诊时的 BMI 之间的关系主要与 BMI 无关，但调整 5 岁时的 BMI 可使关联的幅度降低约 55%。年龄和 BMI 都与 10 岁以后的 BMI 和肥胖独立相关。然而，与年龄相比，儿童的 BMI 和 5 岁及 7 岁时的 BMI 更能解释 10 岁以后 BMI 水平的变异性。
