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在一个大型电子健康记录数据库中,儿童身高与随后肥胖的纵向关系。

The Longitudinal Relation of Childhood Height to Subsequent Obesity in a Large Electronic Health Record Database.

机构信息

Division of Nutrition, Physical Activity, and Obesity, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Departments of Pediatrics and Public Health Science, Penn State College of Medicine, Hershey, Pennsylvania, USA.

出版信息

Obesity (Silver Spring). 2020 Sep;28(9):1742-1749. doi: 10.1002/oby.22901. Epub 2020 Jul 7.

DOI:10.1002/oby.22901
PMID:32638501
Abstract

OBJECTIVE

Several cross-sectional studies have shown that height in childhood is correlated with BMI and with body fatness, and two longitudinal studies have reported that childhood height is associated with adult BMI. This study explored this longitudinal association in an electronic health record database of 2.8 million children.

METHODS

Children were initially examined between the ages of 2 and 13.9 years and, on average, were reexamined 4 years later.

RESULTS

As expected, there was a cross-sectional correlation between height-for-age z score and BMI that increased from r = -0.06 (age of 2 years) to r = 0.37 (age of 9-10 years). In addition, height-for-age at the first visit was related to subsequent BMI and obesity, with the prevalence of subsequent obesity increasing about fourfold over six categories of height-for-age at the first visit. About 40% of this longitudinal association was independent of initial BMI, but its magnitude decreased with initial age. For example, the initial height-for-age of children who were 12 years of age or older was only weakly associated with subsequent BMI.

CONCLUSIONS

Health professionals should recognize that greater childhood height-for-age before 12 years of age may be a marker for increased risk of subsequent obesity.

摘要

目的

几项横断面研究表明,儿童期身高与 BMI 和体脂肪有关,两项纵向研究报告称,儿童期身高与成年 BMI 相关。本研究在一个包含 280 万儿童的电子健康记录数据库中探索了这种纵向关联。

方法

儿童最初在 2 至 13.9 岁之间接受检查,平均 4 年后再次接受检查。

结果

正如预期的那样,身高年龄 z 评分与 BMI 之间存在横断面相关性,该相关性从 r = -0.06(2 岁时)增加到 r = 0.37(9-10 岁时)。此外,首次就诊时的身高与随后的 BMI 和肥胖有关,首次就诊时身高年龄的 6 个类别中,随后肥胖的患病率增加了约 4 倍。约 40%的这种纵向关联与初始 BMI 无关,但随着初始年龄的增加,其程度会降低。例如,12 岁或以上儿童的初始身高年龄与随后的 BMI 相关性较弱。

结论

健康专业人员应认识到,12 岁之前儿童期身高较高可能是随后肥胖风险增加的标志。

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