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The Long and Winding Road from GWAS to Obstructive Lung Disease: Is There a Role for LRP1?

作者信息

Yao Xianglan, Levine Stewart J

机构信息

Laboratory of Asthma and Lung Inflammation National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, Maryland.

出版信息

Am J Respir Cell Mol Biol. 2021 Mar;64(3):279-280. doi: 10.1165/rcmb.2020-0567ED.

DOI:10.1165/rcmb.2020-0567ED
PMID:33352084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7909341/
Abstract
摘要

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1
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2
Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores.LRP1 的缺失促进了收缩型肌成纤维细胞表型的获得和 ECM 库中活性 TGF-β1 的释放。
Matrix Biol. 2020 Jun;88:69-88. doi: 10.1016/j.matbio.2019.12.001. Epub 2019 Dec 11.
3
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.新的肺功能遗传信号突出了多种血统中的途径和慢性阻塞性肺疾病的关联。
Nat Genet. 2019 Mar;51(3):481-493. doi: 10.1038/s41588-018-0321-7. Epub 2019 Feb 25.
4
The APOE ε4 allele is associated with a reduction in FEV1/FVC in women: A cross-sectional analysis of the Long Life Family Study.APOE ε4 等位基因与女性的 FEV1/FVC 降低有关：长寿家族研究的横断面分析。
PLoS One. 2018 Nov 9;13(11):e0206873. doi: 10.1371/journal.pone.0206873. eCollection 2018.
5
Mechanisms by Which LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1) Maintains Arterial Integrity.低密度脂蛋白受体相关蛋白1（LRP1）维持动脉完整性的机制
Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2548-2549. doi: 10.1161/ATVBAHA.118.311882.
6
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.多民族荟萃分析确定了肺功能的种族特异性和跨种族基因座。
Nat Commun. 2018 Jul 30;9(1):2976. doi: 10.1038/s41467-018-05369-0.
7
Low-density lipoprotein receptor-related protein 1 attenuates house dust mite-induced eosinophilic airway inflammation by suppressing dendritic cell-mediated adaptive immune responses.低密度脂蛋白受体相关蛋白 1 通过抑制树突状细胞介导的适应性免疫应答来减轻屋尘螨诱导的嗜酸性气道炎症。
J Allergy Clin Immunol. 2018 Oct;142(4):1066-1079.e6. doi: 10.1016/j.jaci.2017.10.044. Epub 2017 Dec 21.
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Spirometry: a historical gallery up to 1905.肺量计：截至1905年的历史图鉴。
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LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system.载脂蛋白相关蛋白 1：动脉粥样硬化、癌症和神经系统损伤中炎症的调节剂。
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10
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.全基因组关联和大规模随访研究确定了 16 个新的影响肺功能的基因座。
Nat Genet. 2011 Sep 25;43(11):1082-90. doi: 10.1038/ng.941.