The Long and Winding Road from GWAS to Obstructive Lung Disease: Is There a Role for LRP1?
作者信息
Yao Xianglan, Levine Stewart J
机构信息
Laboratory of Asthma and Lung Inflammation National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, Maryland.
出版信息
Am J Respir Cell Mol Biol. 2021 Mar;64(3):279-280. doi: 10.1165/rcmb.2020-0567ED.
Abstract
摘要
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2
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New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.新的肺功能遗传信号突出了多种血统中的途径和慢性阻塞性肺疾病的关联。
Nat Genet. 2019 Mar;51(3):481-493. doi: 10.1038/s41588-018-0321-7. Epub 2019 Feb 25.
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The APOE ε4 allele is associated with a reduction in FEV1/FVC in women: A cross-sectional analysis of the Long Life Family Study.APOE ε4 等位基因与女性的 FEV1/FVC 降低有关：长寿家族研究的横断面分析。
PLoS One. 2018 Nov 9;13(11):e0206873. doi: 10.1371/journal.pone.0206873. eCollection 2018.
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Mechanisms by Which LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1) Maintains Arterial Integrity.低密度脂蛋白受体相关蛋白1（LRP1）维持动脉完整性的机制
Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2548-2549. doi: 10.1161/ATVBAHA.118.311882.
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