性别调节 COMT Val158Met 单核苷酸多态性与新奇寻求紊乱维度之间的关联。
Sex moderates the association between the COMT Val158Met single-nucleotide polymorphism and disorderliness facet of novelty seeking.
机构信息
Department of Psychology, Section of Neuroscience and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, 00185, Rome, Italy.
Department of Psychology, Section of Neuroscience and Center for Research in Neurobiology 'Daniel Bovet', Sapienza University of Rome, 00185, Rome, Italy.
出版信息
Neurosci Res. 2021 Sep;170:364-369. doi: 10.1016/j.neures.2020.10.002. Epub 2020 Dec 19.
Previous studies have shown inconsistent results regarding the effect of the ValMet polymorphism of the catechol-O-methyltransferase (COMT) gene on personality and cognition. Here, nonclinical Caucasian university students of Italian origin were administered the Temperament and Character Inventory-Revised, Tellegen Absorption Scale, Differential Attentional Processes Inventory, and Waterloo-Stanford Group Scale of Hypnotic Susceptibility. We found that the COMT ValMet polymorphism was significantly associated with the disorderliness facet of novelty seeking (NS4) and that sex was a moderator of this association. Females with the Met/Met genotype showed higher NS4 scores compared to those with the Val/Met and Val/Val genotypes. No significant genotype effect was found for males. Additionally, we failed to find a significant effect of the COMT gene on attention and hypnotic suggestibility measures. These results provide further evidence for a sex-specific influence on the gene-behaviour associations.
先前的研究表明，儿茶酚氧位甲基转移酶（COMT）基因的 ValMet 多态性对人格和认知的影响结果并不一致。在这里，我们对非临床的意大利裔白人大学生进行了气质与性格量表修订版、特尔根吸收量表、差异注意过程量表和滑铁卢-斯坦福组催眠易感性量表的测试。我们发现，COMT ValMet 多态性与寻求新奇的不规则性方面（NS4）显著相关，而性别是这种关联的调节因素。与 Val/Met 和 Val/Val 基因型相比，携带 Met/Met 基因型的女性表现出更高的 NS4 评分。而对于男性，没有发现显著的基因型效应。此外，我们未能发现 COMT 基因对注意力和催眠暗示性测量的显著影响。这些结果为基因-行为关联的性别特异性影响提供了进一步的证据。
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