Department of Neurology, Division of Child Neurology, Columbia University Irving Medical Center, New York, NY 10032, United States; Department of Pediatrics, Columbia University Irving Medical Center, Morgan Stanley Children's Hospital, New York, NY 10032, United States.
Department of Pediatrics, Division of Pediatric Critical Care and Hospital Medicine, Columbia University Irving Medical Center, New York, NY 10032, United States.
Neurosci Lett. 2021 Jan 19;743:135567. doi: 10.1016/j.neulet.2020.135567. Epub 2020 Dec 19.
Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious disease course in children, but serious complications may occur in conjunction with both acute infection and associated phenomena such as the multisystem inflammatory syndrome in children (MIS-C). Neurological symptoms, which have been predominantly reported in adults, range from mild headache to seizure, peripheral neuropathy, stroke, demyelinating disorders, and encephalopathy. Similar to respiratory and cardiac manifestations of COVID-19, neurological complications present differently based on age and underlying comorbidities. This review provides a concise overview of the neurological conditions seen in the context of COVID-19, as well as potential mechanisms and long-term implications of COVID-19 in the pediatric population from literature reviews and primary data collected at NewYork-Presbyterian Morgan Stanley Children's Hospital.
2019 年冠状病毒病（COVID-19）通常在儿童中导致轻度传染病过程，但在急性感染和相关现象（如儿童多系统炎症综合征（MIS-C））的同时，可能会发生严重并发症。神经系统症状主要在成年人中报告，从轻度头痛到癫痫、周围神经病、中风、脱髓鞘疾病和脑病不等。与 COVID-19 的呼吸和心脏表现类似，神经系统并发症根据年龄和潜在合并症而有所不同。本综述通过文献回顾和在纽约长老会摩根斯坦利儿童医院收集的原始数据，提供了 COVID-19 背景下神经系统疾病的简要概述，以及 COVID-19 在儿科人群中的潜在机制和长期影响。
