Research Center of Health and Environment, Guilan University of Medical Sciences, Rasht, Iran; Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran.
Sci Total Environ. 2020 Sep 15;735:139417. doi: 10.1016/j.scitotenv.2020.139417. Epub 2020 May 15.
Airborne particulate matter is associated with increasing the risk of cardiovascular diseases. The purpose of this study was to investigate the association between air pollution conditions and MDA, vWF, and fibrinogen markers in the blood of two panels of healthy young individuals in an urban area in Tehran city with a high air pollution background and another group was living in a rural area (Ahmad Abad Mostofi), with a low air pollution background. In each group, 4 blood samples were taken as follows: one in inversion days, the second in winter, but during the existence of normal condition in terms of air pollution, the third sample in the spring during the normal condition in terms of air pollution and the fourth sample during the dust storm conditions. In the urban and rural groups, there was a significant difference between the concentration of MDA, vWF, fibrinogen between inversion and cold season control conditions, and between dust storm conditions and warm season control conditions (p < 0.05). The results showed that the association of dust storm condition on the measured biomarkers was stronger than the inversion condition, which health consideration in the dust conditions be taken into account similar to the inversion conditions.
空气中的悬浮颗粒物与心血管疾病风险的增加有关。本研究的目的是调查空气污染条件与 MDA、vWF 和纤维蛋白原标志物之间的关联，研究对象为两组居住在德黑兰市（空气污染背景较高）的健康年轻个体和另一组居住在农村地区（Ahmad Abad Mostofi）（空气污染背景较低）的个体。在每组中，采集了 4 份血液样本：一份在反转日，第二份在冬季，但在空气污染正常条件下，第三份在春季在空气污染正常条件下，第四份在沙尘暴条件下。在城市和农村组中，MDA、vWF、纤维蛋白原在反转和寒冷季节对照条件之间以及在沙尘暴条件和温暖季节对照条件之间的浓度存在显著差异（p<0.05）。结果表明，沙尘暴条件对测量生物标志物的影响比反转条件更强，因此在沙尘暴条件下应考虑到与反转条件类似的健康因素。
