Lim H C, Chong O K, Chan S H
Department of Physiology, Faculty of Medicine, National University of Singapore, Kent Ridge.
Exp Neurol. 1988 Jan;99(1):133-41. doi: 10.1016/0014-4886(88)90133-1.
Subcutaneous administration of guanabenz (1, 2, 5, or 8 mg/kg) in conscious Sprague-Dawley rats exerted concomitant suppressive actions on systolic pressure (tail-cuff sphygmomanometric measurement) and pain responses (hot-plate algesio-metric assay) that varied both in degree (antinociception much greater than hypotension) and response pattern. Furthermore, both depressive effects were appreciably attenuated by bilateral lesions of the nucleus reticularis gigantocellularis in the medulla oblongata. It is speculated that separate subpopulations of neurons within this reticular nucleus may be involved in the expression of hypotension and antinociception by this amino-guanidine derivative.
在清醒的斯普拉格-道利大鼠中皮下注射胍那苄（1、2、5或8毫克/千克），对收缩压（尾袖式血压测量）和疼痛反应（热板测痛试验）同时产生抑制作用，其程度（镇痛作用远大于低血压作用）和反应模式各不相同。此外，延髓巨细胞网状核的双侧损伤可明显减弱这两种抑制作用。据推测，该网状核内不同的神经元亚群可能参与了这种氨基胍衍生物引起的低血压和镇痛作用的表达。
