Chan J Y, Chan S H
Exp Neurol. 1987 Apr;96(1):233-6. doi: 10.1016/0014-4886(87)90186-5.
Based on the hot-plate algesiometric assay in conscious Sprague-Dawley rats, we observed that both guanabenz and clonidine, at a subcutaneous dose of 5 and 1 mg/kg, respectively, exhibited significant antinociceptive potencies. Paradoxical actions on the hot-plate responses, however, were exerted by guanabenz at lower doses, varying from hyperalgesia (1 mg/kg) to no effect (2 mg/kg). A pretreatment of clonidine (1 mg/kg) substantially potentiated the antinociceptive efficacy of the two latter doses, but failed to further augment the pain-suppressive action of guanabenz at 5 mg/kg. These interactive effects of the two alpha-adrenoceptor agonists suggest that they may share a common mechanism(s) in their analgesic actions.
基于对清醒的斯普拉格-道利大鼠进行的热板测痛法试验，我们观察到，胍那苄和可乐定分别以5毫克/千克和1毫克/千克的皮下注射剂量给药时，均表现出显著的镇痛效力。然而，较低剂量的胍那苄对热板反应产生了矛盾的作用，从痛觉过敏（1毫克/千克）到无作用（2毫克/千克）不等。可乐定（1毫克/千克）预处理显著增强了后两个剂量的镇痛效果，但未能进一步增强胍那苄5毫克/千克剂量的镇痛作用。这两种α-肾上腺素能激动剂的这些相互作用表明，它们在镇痛作用中可能具有共同的机制。
