Faculty of Sport Sciences, Universidad Europea de Madrid, 18670 Madrid, Spain.
Hospital San Juan de Dios, Santa Cruz de Tenerife, 38009 Canary Islands, Spain.
Int J Environ Res Public Health. 2020 Dec 18;17(24):9512. doi: 10.3390/ijerph17249512.
We studied the effects of a supervised, structured exercise program in a severe sarcoidosis patient.
After being clinically stable for two years, a 52-year-old woman (stage IV, American Thoracic Society) who originally had irreversible lung fibrosis, pulmonary arterial hypertension (PAH), mild mitral insufficiency, and atrial dilatation, and was candidate for lung transplant, performed a combined high-intensity interval, high load resistance, and inspiratory muscle training for 4.5 years, and was tested (cardiopulmonary exercise testing and dual X-ray absorptiometry) every six months.
Cardiorespiratory fitness (CRF) and maximal pulmonary ventilation increased by 44% and 60%, respectively. Ventilatory efficiency also improved (decrease in the ventilatory equivalent for oxygen by 32% and 14% at the ventilatory threshold and respiratory compensation point, respectively). She improved New York Heart Association (NYHA) class (from III to II), and cardiac alterations as well as PAH reversed so that she was not in need of lung transplantation anymore. Likewise, she suffered no more episodes of hemoptysis. Bone health was overall maintained despite the post-menopausal status and the corticoid treatment.
A long-term combined exercise intervention safely contributed-at least partly-to improve CRF and NYHA class in a patient with severe sarcoidosis, suggesting a potential coadjuvant effect to attenuate clinical manifestations.
我们研究了监督、结构化运动方案对严重结节病患者的影响。
在临床稳定两年后，一位 52 岁的女性（美国胸科学会第四阶段），最初患有不可逆性肺纤维化、肺动脉高压（PAH）、轻度二尖瓣关闭不全和心房扩张，且为肺移植候选者，进行了为期 4.5 年的高强度间歇、高负荷阻力和吸气肌训练的综合训练，并每六个月进行一次测试（心肺运动测试和双能 X 线吸收法）。
心肺功能（CRF）和最大肺通气量分别增加了 44%和 60%。通气效率也得到了改善（氧通气当量分别在通气阈值和呼吸补偿点下降了 32%和 14%）。她的纽约心脏协会（NYHA）心功能分级（从 III 级到 II 级）得到改善，心脏改变和 PAH 逆转，因此不再需要进行肺移植。同样，她不再咯血。尽管处于绝经后状态和皮质激素治疗中，但骨健康总体上得以维持。
长期联合运动干预至少部分有助于改善严重结节病患者的 CRF 和 NYHA 心功能分级，提示其具有减轻临床表现的潜在辅助作用。
