Department of Ophthalmology, Hopital Intercommunal and Paris Est University, Créteil, France.
Ophthalmic Center for Imaging and Laser, Paris, France.
Eur J Ophthalmol. 2021 Nov;31(6):3182-3189. doi: 10.1177/1120672120983191. Epub 2020 Dec 22.
To evaluate the effects of the Navilas system guided by optical coherence tomography angiography for advanced macular neovascularization (MNV) secondary to age-related macular degeneration (AMD).
Prospective case-series including nine eyes presenting with advanced MNV with persistence of exudative signs, no longer responding to anti-VEGF therapy, best-corrected visual acuity at least of 1.3 logMar. All patients were treated with Navilas guided by overlaid optical coherence tomography angiography (OCTA) images at the site of branching large neovascular trunks.
Occlusion of large neovascular trunks successfully occurred in all nine included patients. OCTA analysis revealed, at 1 month follow up, MNV total area decreasing from 6.2 ± 3.1 to 2.6 ± 3.4 mm. At 6 months follow up, mean MNV area was 3.3 ± 3.4 mm ( = 0.008).
This preliminary study showed that Navilas treatment guided by OCTA may represent an attractive therapeutic option in advanced neovascular lesions secondary to AMD.
评估光学相干断层扫描血管造影引导下的 Navilas 系统治疗与年龄相关性黄斑变性（AMD）相关的晚期黄斑新生血管化（MNV）的效果。
前瞻性病例系列研究纳入 9 只眼，这些眼均患有晚期 MNV，有渗出性体征持续存在，对抗血管内皮生长因子治疗不再有反应，最佳矫正视力至少为 1.3 logMAR。所有患者均在分支大新生血管干处叠加光学相干断层扫描血管造影（OCTA）图像的指导下接受 Navilas 治疗。
9 例患者的大新生血管干均成功闭塞。OCTA 分析显示，在 1 个月的随访中，MNV 总面积从 6.2±3.1mm 减少到 2.6±3.4mm。在 6 个月的随访中，平均 MNV 面积为 3.3±3.4mm（ = 0.008）。
这项初步研究表明，OCTA 引导下的 Navilas 治疗可能是 AMD 相关晚期新生血管病变的一种有吸引力的治疗选择。
