School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Division of Head and Neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Eur J Ophthalmol. 2021 Nov;31(6):3164-3176. doi: 10.1177/1120672120986370. Epub 2021 Jan 14.
To analyze different clinical and anatomical features in treatment-naïve non-exudative macular neovascularizations (MNVs) secondary to age-related macular disease (AMD).
In this retrospective longitudinal study with a minimum follow-up of 1 year, 31 eyes of 28 consecutive AMD patients (mean age 75 ± 9 years) with treatment-naïve non-exudative MNV were enrolled. Patients were divided in: short-term activated MNV group (exudation before 6-month) and quiescent MNV group (per definition no exudation during a minimum 6-month follow-up) showing no or late activation during follow-up (persistently quiescent and long-term activated MNV group, respectively).
During the follow-up (mean duration: 22 ± 9 months) four eyes (13%) showed exudation before 6-month follow-up (short-term activated MNV group), whereas 21 eyes (68%) did not develop signs of exudation (persistently quiescent group), and six eyes (19%) developed exudation after the minimum 6-month follow-up (long-term activated MNV group). Monthly MNV growth rate was significantly higher in the short-term activated MNV group (growth rate of 13.30%/month), vs persistently quiescent MNV group (0.64%/month, < 0.001) and long-term activated quiescent MNV group (1.07%/month, < 0.001). Furthermore, at the baseline, perfusion density of short-term activated MNV group was significantly greater in comparison to persistently quiescent MNV group ( = 0.001) and long-term activated MNV group ( = 0.106).
We reported two different patterns for subclinical MNVs: subclinical MNVs characterized by short-term activation which could represent simply a pre-exudative stage in the development of an ordinary type 1 MNV, and quiescent MNVs characterized by low rate of growth and possible long-term activation. Analysis of OCT-A features may predict short-term activation for subclinical MNV but no features could predict the long-term activation.
分析与年龄相关性黄斑变性（AMD）相关的未经治疗的非渗出性黄斑新生血管（MNV）的不同临床和解剖特征。
在这项回顾性纵向研究中，对 28 例连续 AMD 患者的 31 只眼（平均年龄 75±9 岁）进行了治疗，这些患者均为未经治疗的非渗出性 MNV，随访时间至少为 1 年。患者分为：短期活动性 MNV 组（6 个月前有渗出）和静止性 MNV 组（定义为至少 6 个月的随访期间无渗出），在随访期间无或迟发性激活（分别为持续静止和长期活动性 MNV 组）。
在随访期间（平均持续时间为 22±9 个月），4 只眼（13%）在 6 个月的随访前出现渗出（短期活动性 MNV 组），而 21 只眼（68%）未出现渗出迹象（持续静止组），6 只眼（19%）在至少 6 个月的随访后出现渗出（长期活动性 MNV 组）。短期活动性 MNV 组的 MNV 每月增长率明显更高（13.30%/月），与持续静止性 MNV 组（0.64%/月，<0.001）和长期活动性静止性 MNV 组（1.07%/月，<0.001）相比。此外，在基线时，短期活动性 MNV 组的灌注密度明显大于持续静止性 MNV 组（ = 0.001）和长期活动性静止性 MNV 组（ = 0.106）。
我们报道了两种不同类型的亚临床 MNV：以短期活动为特征的亚临床 MNV 可能只是普通 1 型 MNV 发展的前渗出阶段，而以低生长率和可能长期活动为特征的静止性 MNV。OCT-A 特征分析可能预测亚临床 MNV 的短期活动，但没有特征可以预测长期活动。
