School of Veterinary Medicine, University College Dublin (UCD), Belfield, Dublin 4, Ireland.
Ther Deliv. 2021 Jan;12(1):21-36. doi: 10.4155/tde-2020-0099. Epub 2020 Dec 23.
Burst release of encapsulated drug with release of a significant fraction of payload into release medium within a short period, both and , remains a challenge for translation. Such unpredictable and uncontrolled release is often undesirable, especially from the perspective of developing sustained-release formulations. Moreover, a brisk release of the payload upsets optimal release kinetics. This account strives toward understanding burst release noticed in nanocarriers and investigates its causes. Various mathematical models to explain such untimely release were also examined, including their strengths and weaknesses. Finally, the account revisits current techniques of limiting burst release from nanocarriers and prioritizes future directions that harbor potential of fruitful translation by reducing such occurrences.
囊泡药物在短时间内将大部分药物有效成分释放到释放介质中，这种爆发式释放一直是转化研究的一个挑战。这种不可预测和不受控制的释放通常是不理想的，尤其是从开发缓释制剂的角度来看。此外，药物有效成分的快速释放会打乱最佳释放动力学。本报告旨在了解纳米载体中观察到的爆发式释放，并探讨其原因。还研究了各种解释这种不合时宜释放的数学模型，包括它们的优缺点。最后，本报告重新审视了目前限制纳米载体中爆发式释放的技术，并通过减少这种情况的发生，为具有转化潜力的未来方向确定了优先级。
