Odent Jérémy, Baleine Nicolas, Torcasio Serena Maria, Gautier Sarah, Coulembier Olivier, Raquez Jean-Marie
Laboratory of Polymeric and Composite Materials (LPCM), Center of Innovation and Research in Materials and Polymers (CIRMAP), University of Mons (UMONS), Place du Parc 20, 7000 Mons, Belgium.
Polymers (Basel). 2024 Sep 3;16(17):2502. doi: 10.3390/polym16172502.
Diabetes is a major health concern that the next-generation of on-demand insulin releasing implants may overcome via personalized therapy. Therein, 3D-printed phenylboronic acid-containing implants with on-demand glucose-triggered drug release abilities are produced using high resolution stereolithography technology. To that end, the methacrylation of phenylboronic acid is targeted following a two-step reaction. The resulting photocurable phenylboronic acid derivative is accordingly incorporated within bioinert polyhydroxyethyl methacrylate-based hydrogels at varying loadings. The end result is a sub-centimeter scaled 3D-printed bioinert implant that can be remotely activated with 1,2-diols and 1,3-diols such as glucose for on-demand drug administration such as insulin. As a proof of concept, varying glucose concentration from hypoglycemic to hyperglycemic levels readily allow the release of pinacol, i.e., a 1,2-diol-containing model molecule, at respectively low and high rates. In addition, the results demonstrated that adjusting the geometry and size of the 3D-printed part is a simple and suitable method for tailoring the release behavior and dosage.
糖尿病是一个重大的健康问题，下一代按需释放胰岛素的植入物可能通过个性化治疗来克服这一问题。在这方面，使用高分辨率立体光刻技术制造了具有按需葡萄糖触发药物释放能力的3D打印含苯硼酸植入物。为此，通过两步反应对苯硼酸进行甲基丙烯酸化。由此产生的可光固化苯硼酸衍生物相应地以不同的负载量掺入基于甲基丙烯酸羟乙酯的生物惰性水凝胶中。最终结果是一个亚厘米级的3D打印生物惰性植入物，它可以用1,2 -二醇和1,3 -二醇（如葡萄糖）远程激活，用于按需给药，如胰岛素。作为概念验证，从低血糖到高血糖水平改变葡萄糖浓度能够分别以低速率和高速率释放频哪醇，即一种含1,2 -二醇的模型分子。此外，结果表明，调整3D打印部件的几何形状和尺寸是一种简单且合适的方法，可用于定制释放行为和剂量。
