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巴基斯坦俾路支省皮肤利什曼病的流行病学和病理学特征。

Epidemiological and pathological characteristics of Cutaneous Leishmaniasis from Baluchistan Province of Pakistan.

机构信息

Department of Biosciences, COMSATS University Islamabad, Park Road, Chak Shahzad, Islamabad, Pakistan.

Department of histopathology, Bolan Medical Complex Hospital, Quetta, Pakistan.

出版信息

Parasitology. 2021 Apr;148(5):591-597. doi: 10.1017/S0031182020002413. Epub 2020 Dec 23.


DOI:10.1017/S0031182020002413
PMID:33353570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10950375/
Abstract

Cutaneous Leishmaniasis (CL) is considered a neglected tropical disease which in Pakistan can now be considered as a growing public health problem. The exact figures on the magnitude of the disease are lacking both at the national and regional level and only a few health centres are available for diagnosis of CL. The present study was designed to identify the epidemiology of CL infection from August 2018 to December 2019 and to assess clinical aspects of CL in Baluchistan Province of Pakistan. A total of 4072 clinically suspected CL cases were analysed statistically. The highest number of CL cases were reported in May, followed by April, January and then July, February and June and the lowest number of cases were observed in March and November. The highest prevalence rate was found in males where 38% of reported cases were aged 0-9 years. The majority (24.4%) of lesions were found on the hands followed by the face in which cheeks, ears and nose were the effected organs. About 50% of the participants have single lesion while 14% of the participants had two and nearly 3% of the participants have six lesions. The atypical clinical presentations were observed in Baluchistan and common unusual presentations were lupus erythematosus. The study findings suggest that more epidemiological studies and health education campaigns are needed for the population awareness regarding CL in Baluchistan. It is recommended that risk factors should be evaluated to establish control and management strategies to prevent disease at the individual and community level.

摘要

皮肤利什曼病(CL)被认为是一种被忽视的热带病,在巴基斯坦,它现在可以被视为一个日益严重的公共卫生问题。无论是在国家层面还是在地区层面,都缺乏关于该疾病严重程度的确切数据,只有少数几个卫生中心可以诊断 CL。本研究旨在确定 2018 年 8 月至 2019 年 12 月期间 CL 感染的流行病学,并评估巴基斯坦俾路支省 CL 的临床方面。对总共 4072 例临床疑似 CL 病例进行了统计学分析。报告的 CL 病例数量最多的是 5 月,其次是 4 月、1 月,然后是 7 月、2 月和 6 月,数量最少的是 3 月和 11 月。男性 CL 发病率最高,报告的病例中有 38%为 0-9 岁。大多数(24.4%)病变发生在手,其次是脸,面颊、耳朵和鼻子是受影响的器官。约 50%的参与者有单个病变,14%的参与者有两个病变,近 3%的参与者有六个病变。在俾路支省观察到非典型临床表现,常见的不寻常表现是红斑狼疮。研究结果表明,需要在俾路支省开展更多的流行病学研究和健康教育活动,提高民众对 CL 的认识。建议评估风险因素,以制定个人和社区层面的控制和管理策略,预防疾病。

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Evaluation of Household Preparedness and Risk Factors for Cutaneous Leishmaniasis (CL) Using the Community Assessment for Public Health Emergency Response (CASPER) Method in Pakistan.

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本文引用的文献

[1]
Cutaneous Leishmaniasis (CL): A Cross-Sectional Community Based Survey on Knowledge, Attitude and Practices in a Highly Endemic Area of Waziristan (KPK Province), Pakistan.

Acta Trop. 2021-1

[2]
The Geographical Distribution of Cutaneous Leishmaniasis Causative Agents in Iran and Its Neighboring Countries, A Review.

Front Public Health. 2020-2-18

[3]
Molecular epidemiological survey of cutaneous leishmaniasis from Azad Jammu and Kashmir, Pakistan.

Acta Trop. 2020-2-29

[4]
Leishmaniasis in Pakistan: A call for action.

Travel Med Infect Dis. 2019

[5]
Prevalence and environmental determinants of cutaneous leishmaniasis in rural communities in Tigray, northern Ethiopia.

PLoS Negl Trop Dis. 2019-9-26

[6]
The current clinical and geographical situation of cutaneous leishmaniasis based on species identification in Turkey.

Acta Trop. 2019-2

[7]
Promising nanotherapy in treating leishmaniasis.

Int J Pharm. 2018-6-8

[8]
Clinical practice guidelines for the diagnosis and treatment of cutaneous leishmaniasis in Turkey.

Int J Dermatol. 2018-4-16

[9]
Clinical and epidemiological characteristics of cutaneous leishmaniasis in Sri Lanka.

BMC Infect Dis. 2018-3-6

[10]
Epidemiology of Cutaneous Leishmaniasis Outbreak, Waziristan, Pakistan.

Emerg Infect Dis. 2018-1

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