Rapid effective dose calculation for raster-scanning He ion therapy with the modified microdosimetric kinetic model (mMKM).

PURPOSE

To develop and verify effective dose (D) calculation in He ion beam therapy based on the modified microdosimetric kinetic model (mMKM) and evaluate the bio-sensitivity of mMKM-based plans to clinical parameters using a fast analytical dose engine.

METHODS

Mixed radiation field particle spectra (MRFS) databases have been generated with Monte-Carlo (MC) simulations for He-ion beams. Relative biological effectiveness (RBE) and D calculation using MRFS were established within a fast analytical engine. Spread-out Bragg-Peaks (SOBPs) in water were optimized for two dose levels and two tissue types with photon linear-quadratic model parameters α, β, and (α/β) to verify MRFS-derived database implementation against computations with MC-generated mixed-field α and β databases. Bio-sensitivity of the SOBPs was investigated by varying absolute values of β, while keeping (α/β) constant. Additionally, dose, dose-averaged linear energy transfer, and bio-sensitivity were investigated for two patient cases.

RESULTS

Using MRFS-derived databases, dose differences ≲2% in the plateau and SOBP are observed compared to computations with MC-generated databases. Bio-sensitivity studies show larger deviations when altering the absolute β value, with maximum D changes of ~5%, with similar results for patient cases. Bio-sensitivity analysis indicates a greater impact on D varying (α/β) than β in mMKM.

CONCLUSIONS

The MRSF approach yielded negligible differences in the target and small differences in the plateau compared to MC-generated databases. The presented analyses provide guidance for proper implementation of RBE-weighted He ion dose prescription and planning with mMKM. The MRFS-D calculation approach using mMKM will be implemented in a clinical treatment planning system.