Naash M I, Nielsen J C, Anderson R E
Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030.
Invest Ophthalmol Vis Sci. 1988 Jan;29(1):149-52.
The activities of glutathione peroxidase (GSH-Px) and glutathione-S-transferase (GSH-S-tase) were investigated in adult and premature human retinas. The measurements were done in the vascular and avascular regions of premature retinas at gestational age of 22-33 weeks and in the central, mid-peripheral, and far peripheral regions of mature retinas from the age of 1 month to 73 years. Among the premature infants, those who survived for greater than 24 hours were supplemented with alpha-tocopherol (vitamin E) on a periodic basis. The vascular and avascular regions of premature retinas had higher activities of GSH-Px when compared to the central and far peripheral regions of mature retinas. Infants surviving more than 24 hr had higher activities of GSH-S-tase in the avascular region than infants who survived less than 24 hr. Survival did not affect either enzyme activity in the vascular regions. Mature retinas showed a decrease in GSH-Px specific activity with age, but no age-related changes in GSH-S-tase were observed. These data demonstrate that premature infants are born with relatively high levels of GSH-Px and GSH-S-tase.
在成人和早产人类视网膜中研究了谷胱甘肽过氧化物酶（GSH-Px）和谷胱甘肽-S-转移酶（GSH-S-tase）的活性。测量在孕龄22至33周的早产视网膜的血管和无血管区域以及1个月至73岁成熟视网膜的中央、中周和远周区域进行。在早产儿中，存活超过24小时的婴儿定期补充α-生育酚（维生素E）。与成熟视网膜的中央和远周区域相比，早产视网膜的血管和无血管区域具有更高的GSH-Px活性。存活超过24小时的婴儿无血管区域的GSH-S-tase活性高于存活少于24小时的婴儿。存活情况对血管区域的两种酶活性均无影响。成熟视网膜的GSH-Px比活性随年龄降低，但未观察到GSH-S-tase有与年龄相关的变化。这些数据表明，早产儿出生时GSH-Px和GSH-S-tase水平相对较高。
