Andrade Susan Kelly Damião do Rego E Silva, de Melo Maria Clara Silva, de Lima Bartolomeu Fagundes, Porto Fábio Henrique de Gobbi, Peixoto Vanessa Giffoni de Medeiros Nunes Pinheiro, Gazzola Juliana Maria
Universidade Federal do Rio Grande do Norte - Natal, RN, Brazil.
Institute of Psychiatry, Universidade de São Paulo - São Paulo, SP, Brazil.
Dement Neuropsychol. 2020 Dec;14(4):387-393. doi: 10.1590/1980-57642020dn14-040009.
The functional capacity of elderly individuals with Alzheimer disease (AD) progressively declines.
To verify the influence of sociodemographic, clinical, staging, mobility, and postural and cognitive balance data on the impairment of the functional capacity of elderly individuals with AD.
This observational, analytical, cross-sectional study was performed at the Physiotherapy Department of the Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. The study consisted of forty elderly individuals aged ≥60 years old with mild or moderate AD, who could ambulate independently. The instruments used included a questionnaire to assess sociodemographic and anthropometric data; the Mini-Mental Health State Examination (MMSE); the Clinical Dementia Rating (CDR); a clock drawing test (CDT); a verbal fluency test (VFT); the Timed Up and Go Test (TUG); and the Clinical Test of Sensory Organization and Balance (CTSIB). Simple descriptive analyses, Mann-Whitney test, Spearman's correlation test, linear regression modeling, and prediction equation (p<0.05, 95% confidence interval [95%CI]) were performed.
Fifteen linear regression models were generated, with the final model chosen for analysis. The variables assumed in that model were CDR, MMSE score, and condition 3 of the CTSIB, which explained 60.1% of the outcome.
Impairment of functional capacity in elderly individuals with AD was influenced by disease progression, which was due to cognitive deficits and deficits in postural balance, which are related to the inaccuracy of the somatosensory system in performing sensory integration.
患有阿尔茨海默病（AD）的老年人的功能能力会逐渐下降。
验证社会人口统计学、临床、分期、活动能力、姿势和认知平衡数据对患有AD的老年人功能能力损害的影响。
这项观察性、分析性横断面研究在巴西北里奥格兰德州纳塔尔市的北里奥格兰德联邦大学物理治疗系进行。该研究包括40名年龄≥60岁、患有轻度或中度AD且能够独立行走的老年人。所使用的工具包括一份评估社会人口统计学和人体测量数据的问卷；简易精神状态检查表（MMSE）；临床痴呆评定量表（CDR）；画钟试验（CDT）；语言流畅性测试（VFT）；定时起立行走测试（TUG）；以及感觉组织和平衡临床测试（CTSIB）。进行了简单描述性分析、曼-惠特尼检验、斯皮尔曼相关性检验、线性回归建模和预测方程（p<0.05，95%置信区间[95%CI]）。
生成了15个线性回归模型，并选择最终模型进行分析。该模型中的变量为CDR、MMSE评分和CTSIB的条件3，它们解释了60.1%的结果。
患有AD的老年人功能能力的损害受疾病进展的影响，这是由于认知缺陷和姿势平衡缺陷所致，这些缺陷与体感系统在进行感觉整合时的不准确有关。
