Mohammed Rasheed Huda A, Hamid Pousette
Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Neurology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2020 Nov 16;12(11):e11516. doi: 10.7759/cureus.11516.
Endometriosis is a disease caused by the implantation of endometrial glands and stroma outside the uterine cavity. It affects 10% of the reproductive-age women this means that 190 million women are affected worldwide. The definitive diagnosis requires surgical exploration or a laparoscopy which is of a high expense. The pathogenesis of the disease is heterogeneous and poorly understood despite the progress in the research field. Infertility is one of the main symptoms of Endometriosis. The mechanism behind this remains unclear. Literature suggests that Endometriosis reduces implantation capacity, increases the risk of pregnancy loss, and causes anatomical obstruction imposed by endometriotic lesions. The disease has a high burden to it by decreasing the quality of women's life and imposing negative consequences for their productivity, social life, and emotional wellbeing. Since inflammation is considered the hallmark of endometriosis, it is worth looking at the mechanism of how inflammation is linked to infertility in endometriosis patients. In this study, we summarized the recent finding of how inflammation can affect oocyte, endometrium, hormones, and sperm.
子宫内膜异位症是一种由子宫内膜腺体和间质在子宫腔外植入引起的疾病。它影响10%的育龄妇女，这意味着全球有1.9亿妇女受到影响。明确诊断需要进行手术探查或腹腔镜检查，费用高昂。尽管该研究领域取得了进展，但该疾病的发病机制是异质性的，且了解甚少。不孕症是子宫内膜异位症的主要症状之一。其背后的机制尚不清楚。文献表明，子宫内膜异位症会降低着床能力，增加流产风险，并导致子宫内膜异位病变造成的解剖学梗阻。该疾病给女性生活质量带来负面影响，并对其生产力、社交生活和情绪健康产生不良后果，负担沉重。由于炎症被认为是子宫内膜异位症的标志，因此值得研究炎症与子宫内膜异位症患者不孕症之间的联系机制。在本研究中，我们总结了炎症如何影响卵母细胞、子宫内膜、激素和精子的最新发现。
