饮食炎症指数与不孕症之间的关联：一项系统评价和荟萃分析。
Association between the dietary inflammatory index and infertility: a systematic review and meta-analysis.
作者信息
Zahedi Yasamin, Bonyanpour Shayan, Alizadeh Seyed Danial, Ravankhah Sarah, Zare Alireza, Izadi Bahareh, Apelian Shant, Sekhavati Eghbal, Tabrizi Reza
机构信息
Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
Sina Trauma and Surgery Research Centre, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Front Nutr. 2025 Aug 26;12:1599782. doi: 10.3389/fnut.2025.1599782. eCollection 2025.
INTRODUCTION
To evaluate the association between the dietary inflammatory index (DII) and risk of infertility in human participants.
METHODS
A comprehensive search was conducted using the Scopus, PubMed, Web of Science, Cochrane, Embase, and Google Scholar databases until January 2025. All observational studies that reported an association between the DII and infertility in human participants were included. Data were extracted on study characteristics, DII scores, and infertility outcomes. Meta-analyses were conducted using random-effects models, and the heterogeneity of studies was evaluated using I statistics.
RESULTS
Of the 801 studies screened, nine met the inclusion criteria, involving 17,711 individuals. The analysis revealed a significant association between a pro-inflammatory diet (characterized by high DII scores) and infertility (odds ratio (OR): 1.61, 95% CI: 1.32-1.95) among participants in the highest quartile of the DII. Additionally, each unit increase in the DII was associated with a 10% higher risk of infertility (OR, 1.10; 95% CI: 1.05-1.15). Subgroup analyses revealed a significant association between anti-inflammatory diets (low DII scores) and infertility in men and increased infertility risk in both the Iranian and US populations and in female participants on a pro-inflammatory diet. The sensitivity analysis indicated that the overall OR remained stable, with the results not being significantly influenced by the exclusion of individual studies.
CONCLUSION
These findings highlight the potential role of inflammation-related dietary factors in reproductive health and suggest that dietary modifications targeting inflammation could be a promising intervention for infertility management. Further randomized controlled trials are needed to confirm these findings and to establish causal relationships.
SYSTEMATIC REVIEW REGISTRATION
This systematic review is registered in PROSPERO with code: CRD42024567145. URL: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024567145.
引言
评估饮食炎症指数（DII）与人类参与者不孕风险之间的关联。
方法
截至2025年1月，使用Scopus、PubMed、Web of Science、Cochrane、Embase和谷歌学术数据库进行了全面检索。纳入所有报告了DII与人类参与者不孕之间关联的观察性研究。提取了关于研究特征、DII评分和不孕结局的数据。使用随机效应模型进行荟萃分析，并使用I统计量评估研究的异质性。
结果
在筛选的801项研究中，有9项符合纳入标准，涉及17711名个体。分析显示，在DII最高四分位数的参与者中，促炎饮食（以高DII评分表征）与不孕之间存在显著关联（优势比（OR）：1.61，95%置信区间：1.32 - 1.95）。此外，DII每增加一个单位，不孕风险就会增加10%（OR，1.10；95%置信区间：1.05 - 1.15）。亚组分析显示，抗炎饮食（低DII评分）与男性不孕之间存在显著关联，并且在伊朗和美国人群以及食用促炎饮食的女性参与者中不孕风险增加。敏感性分析表明，总体OR保持稳定，排除个别研究对结果没有显著影响。
结论
这些发现突出了炎症相关饮食因素在生殖健康中的潜在作用，并表明针对炎症的饮食调整可能是一种有前景的不孕管理干预措施。需要进一步的随机对照试验来证实这些发现并建立因果关系。
系统评价注册
本系统评价已在PROSPERO注册，注册号：CRD42024567145。网址：https://www.crd.york.ac.uk/PROSPERO/view/CRD42024567145
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