Loeffler J S, Tarbell N J, Garber J R, Mauch P
Department of Radiation Therapy, Beth Israel Hospital, Harvard Medical School, Boston, MA 02115.
Int J Radiat Oncol Biol Phys. 1988 Jan;14(1):175-8. doi: 10.1016/0360-3016(88)90065-x.
Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population.
放射性甲状腺功能障碍在接受斗篷野放疗的霍奇金病患者中很常见。虽然化学性和临床性甲状腺功能减退最为常见，但也有格雷夫斯病的相关报道。我们查阅了1969年4月至1980年12月期间接受斗篷野照射的437例手术分期患者的记录，以确定格雷夫斯病表现的发生率。在该组患者中，有7例出现甲状腺功能亢进，并伴有格雷夫斯病典型的眼部表现。在本研究中，霍奇金病患者接受斗篷野照射后10年发生格雷夫斯病的精算风险在女性患者中为3.3%，在男性患者中为1%。女性和男性患者的观察/预期比值分别为5.9和5.1。这一观察到的风险显著超过了一般人群中的风险。
