Gerritsen Cory, Iyengar Yajur, DaSilva Tania, Koppel Alex, Rusjan Pablo, Bagby R Michael, Mizrahi Romina
Forensic Early Intervention Service, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Personal Neurosci. 2020 Nov 24;3:e14. doi: 10.1017/pen.2020.14. eCollection 2020.
Personality has been correlated with differences in cytokine expression, an indicator of peripheral inflammation; however, the associations between personality and central markers of inflammation have never been investigated in humans. Microglia are the resident macrophages of the central nervous system, and the first responders to tissue damage and brain insult. Microglial activation is associated with elevated expression of translocator protein 18kDa (TSPO), which can be imaged with positron emission tomography (PET) to quantify immune activation in the human brain. This study aimed to investigate the association between personality and TSPO expression across the psychosis spectrum. A total of 61 high-resolution [F]FEPPA PET scans were conducted in 28 individuals at clinical high risk (CHR) for psychosis, 19 First-Episode Psychosis (FEP), and 14 healthy volunteers (HVs), and analyzed using a two-tissue compartment model and plasma input function to obtain a total volume of distribution (V) as an index of brain TSPO expression (controlling for the rs6971 TSPO polymorphism). Personality was assessed using the Revised NEO Personality Inventory (NEO-PI-R). We found TSPO expression to be specifically associated with neuroticism. A positive association between TSPO expression and neuroticism was found in HVs, in contrast to a nonsignificant, negative association in CHR and significant negative association in FEP. The TSPO-associated neuroticism trait indicates an unexplored connection between neuroimmune activation and personality that varies across the psychosis spectrum.
人格与细胞因子表达差异相关，细胞因子表达是外周炎症的一个指标；然而，人格与炎症中枢标志物之间的关联从未在人类中进行过研究。小胶质细胞是中枢神经系统的常驻巨噬细胞，是组织损伤和脑损伤的第一反应者。小胶质细胞激活与18kDa转位蛋白（TSPO）表达升高有关，TSPO可通过正电子发射断层扫描（PET）成像，以量化人类大脑中的免疫激活。本研究旨在调查整个精神病谱系中人格与TSPO表达之间的关联。对28名临床高危（CHR）精神病患者、19名首发精神病（FEP）患者和14名健康志愿者（HV）进行了总共61次高分辨率[F]FEPPA PET扫描，并使用双组织室模型和血浆输入函数进行分析，以获得分布总体积（V）作为脑TSPO表达的指标（控制rs6971 TSPO多态性）。使用修订后的大五人格量表（NEO-PI-R）评估人格。我们发现TSPO表达与神经质特质特异性相关。在HV中发现TSPO表达与神经质呈正相关，而在CHR中呈非显著负相关，在FEP中呈显著负相关。与TSPO相关的神经质特质表明神经免疫激活与人格之间存在未被探索的联系，这种联系在整个精神病谱系中有所不同。
