Brady M, Baker C, Neinstein L S
Division of Adolescent Medicine, Childrens Hospital of Los Angeles, CA 90027.
J Adolesc Health Care. 1988 Jan;9(1):72-5. doi: 10.1016/0197-0070(88)90022-8.
This study examined the prevalence of Chlamydia trachomatis infections of the urethra in asymptomatic teenage males in a juvenile detention setting. Gonorrhea cultures, chlamydia smears using the direct immunofluorescent antibody (DFA) technique, and 15-20 ml of a first-catch urine (FCU) sample were obtained. Of the 227 adolescent males screened, 205 had experienced sexual intercourse. Twenty-seven (13.2%) of the sexually active adolescents had positive DFA smears for C. trachomatis. Three (1.5%) had positive Neisseria gonorrhoeae cultures. A urine leukocyte count of greater than 10 per high-power field gave a 91% specificity but only a 26% sensitivity for a positive DFA. The high prevalence of chlamydia in this population and the relative low cost of the DFA screen for chlamydia make this a useful procedure for discovering unsuspected disease, particularly in a high-risk population. The FCU screen for leukocytes was of limited value in identifying asymptomatic infection.
本研究调查了青少年拘留所中无症状青少年男性尿道沙眼衣原体感染的患病率。采集了淋病培养物、采用直接免疫荧光抗体（DFA）技术的衣原体涂片，以及15 - 20毫升初段尿（FCU）样本。在筛查的227名青少年男性中，205人有过性行为。27名（13.2%）性活跃青少年的沙眼衣原体DFA涂片呈阳性。3名（1.5%）淋病奈瑟菌培养呈阳性。每高倍视野尿白细胞计数大于10对DFA阳性的特异性为91%，但敏感性仅为26%。该人群中衣原体的高患病率以及DFA筛查衣原体相对较低的成本，使得这一检查对于发现未被怀疑的疾病很有用，特别是在高危人群中。FCU白细胞筛查在识别无症状感染方面价值有限。
