Department of Obstetrics and Gynecology, People's Hospital, Peking University, Beijing, China.
Gynecol Endocrinol. 2021 Aug;37(8):689-693. doi: 10.1080/09513590.2020.1862789. Epub 2020 Dec 23.
The role of leptin in the development of endometriosis has been investigated previously. However, researches on the change of leptin levels in endometriosis remains controversial. So, we aimed to clarify changes of leptin levels in patients with endometriosis and their association with the progression of endometriosis. We searched PubMed, Embase, Web of Science, and The Cochrane Library to identify relevant studies published before May 25, 2020. The detected levels of leptin in patients with endometriosis versus controls were evaluated in this meta-analysis. Eighteen studies met our inclusion criteria, five studies detected serum, nine detected peritoneal fluid and another four detected both serum and peritoneal fluid leptin levels. The overall results showed that peritoneal fluid leptin levels in patients with endometriosis was significantly higher than that in the control group, but the serum and corrected peritoneal fluid leptin levels were comparable in both groups. Subgroup analysis failed to eliminate the high degree of heterogeneity included in the studies and showed that peritoneal fluid leptin levels were significantly elevated in both early and advanced endometriosis. In conclusion, peritoneal fluid rather than serum leptin levels was elevated in patients with endometriosis, which did not seem to be related to the severity of endometriosis, but was related to body mass index.
先前已有研究探讨瘦素在子宫内膜异位症发展中的作用。然而，关于子宫内膜异位症患者瘦素水平变化的研究仍存在争议。因此，我们旨在阐明子宫内膜异位症患者瘦素水平的变化及其与子宫内膜异位症进展的关系。我们检索了 PubMed、Embase、Web of Science 和 The Cochrane Library，以确定截至 2020 年 5 月 25 日发表的相关研究。本荟萃分析评估了子宫内膜异位症患者与对照组之间瘦素的检测水平。符合纳入标准的研究有 18 项，其中 5 项检测血清，9 项检测腹腔液，另外 4 项检测血清和腹腔液瘦素水平。总体结果表明，子宫内膜异位症患者腹腔液瘦素水平明显高于对照组，但两组血清和校正腹腔液瘦素水平相当。亚组分析未能消除研究中包含的高度异质性，表明早期和晚期子宫内膜异位症患者的腹腔液瘦素水平均显著升高。总之，子宫内膜异位症患者腹腔液而非血清瘦素水平升高，这似乎与子宫内膜异位症的严重程度无关，而是与体重指数有关。
