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我们能在多大程度上将遗传与环境区分开？

How well can we separate genetics from the environment?

机构信息

Human Genetics, University of Chicago, Chicago, United States.

出版信息

Elife. 2020 Dec 23;9:e64948. doi: 10.7554/eLife.64948.

DOI:10.7554/eLife.64948
PMID:33355092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7758058/
Abstract

A simulation study demonstrates a better method for separating genetic effects from environmental effects in genome-wide association studies, but there is still some way to go before this becomes a "solved" problem.

摘要

一项模拟研究表明，在全基因组关联研究中，有一种更好的方法可以分离遗传效应和环境效应，但要解决这个问题，还有很长的路要走。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88a/7758058/3f5350cea4c6/elife-64948-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88a/7758058/3f5350cea4c6/elife-64948-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88a/7758058/3f5350cea4c6/elife-64948-fig1.jpg

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Elife. 2020 Nov 17;9:e61548. doi: 10.7554/eLife.61548.
2
Using genetics for social science.利用遗传学进行社会科学研究。
Nat Hum Behav. 2020 Jun;4(6):567-576. doi: 10.1038/s41562-020-0862-5. Epub 2020 May 11.
3
Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?在遗传生物银行时代，人口结构是否无关紧要、是一个挑战还是一个机会？
成人多基因分数能否提高儿童时期体重指数的预测能力？
Int J Obes (Lond). 2022 Jul;46(7):1375-1383. doi: 10.1038/s41366-022-01130-2. Epub 2022 May 3.
4
Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes.研究综述：如何解释多基因评分、环境风险和表型之间的关联。
J Child Psychol Psychiatry. 2022 Oct;63(10):1125-1139. doi: 10.1111/jcpp.13607. Epub 2022 Mar 28.
Hum Genet. 2020 Jan;139(1):23-41. doi: 10.1007/s00439-019-02014-8. Epub 2019 Apr 27.
4
Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies.由于全基因组关联研究中未校正的分层，身高的多基因适应被高估了。
Elife. 2019 Mar 21;8:e39702. doi: 10.7554/eLife.39702.
5
Reduced signal for polygenic adaptation of height in UK Biobank.英国生物库中身高多基因适应信号降低。
Elife. 2019 Mar 21;8:e39725. doi: 10.7554/eLife.39725.
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Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences.解读多基因评分、多基因适应性和人类表型差异。
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7
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