Department of Biological & Environmental Sciences & Technology, University of Salento, via Monteroni 165, Lecce, 73100, Italy.
Institute for Research on Population & Social Policies, National Research Council, Research Unit of Brindisi, c/o ex Osp. Di Summa, Piazza Di Summa, Brindisi, 72100, Italy.
Epigenomics. 2021 Jan;13(2):145-164. doi: 10.2217/epi-2020-0289. Epub 2020 Dec 23.
The term 'lifestyle' includes different factors that contribute to the maintenance of a good health status. Increasing evidences suggest that lifestyle factors may influence epigenetic mechanisms, such as miRNAs expression. The dysregulation of miRNAs can modify the expression of genes and molecular pathways that may lead to functional alterations. This review summarizes human studies highlighting that diet, physical activity, smoking and alcohol consumption may affect the miRNA machinery and several biological functions. Most miRNAs are involved in molecular pathways that influence inflammation, cell cycle regulation and carcinogenesis resulting in the onset or progression of pathological conditions. Investigating these interactions will be pivotal for understanding the etiology of pathologic processes, the potential new treatment strategies and for preventing diseases.
“生活方式”一词包括有助于维持良好健康状态的不同因素。越来越多的证据表明，生活方式因素可能会影响表观遗传机制，如 miRNA 的表达。miRNA 的失调可以改变基因和分子途径的表达，从而导致功能改变。本综述总结了人类研究，强调饮食、体力活动、吸烟和饮酒可能会影响 miRNA 机制和多种生物学功能。大多数 miRNA 都参与影响炎症、细胞周期调节和致癌作用的分子途径，从而导致病理状况的发生或进展。研究这些相互作用对于理解病理过程的病因、潜在的新治疗策略以及预防疾病将至关重要。
