de Menezes Manuela Rocha, Acioli Maria Eduarda Azevêdo, da Trindade Ana Carolina Lemos, da Silva Suéllen Pedrosa, de Lima Raul Emídio, da Silva Teixeira Vanessa Gabryelle, Vasconcelos Luydson Richardson Silva
Programa de Pós-Graduação em Ciências da Saúde, Universidade de Pernambuco (UPE), 50100-130, Recife, Pernambuco, Brasil.
Laboratório de Biologia Molecular de Doenças Infecciosas, Departamento de Parasitologia, Instituto Aggeu Magalhães (IAM), Fundação Oswaldo Cruz (FIOCRUZ), 50670-420, Recife, Pernambuco, Brasil.
Mol Biol Rep. 2021 May;48(5):4647-4658. doi: 10.1007/s11033-021-06423-9. Epub 2021 May 25.
Glioblastoma (GBM) is the most common, aggressive and malignant type of glioma, with poor prognosis, despite advances in medical knowledge and technology. It's known that some microRNAs (miRNAs) can be dysregulated and associated with tumors. We aim to investigate miRNAs that may have a role as potential biomarkers in human glioblastoma. A search was performed using PubMed, LILACS and SCIELO databases to find papers from 2015 to 2020, related to human in vitro and ex vivo data. From 99 articles, 10 were eligible and 13 dysregulated miRNAs were found with description of regulation, target(s), pathway(s) and mechanism(s). The miRNAs of interest were found and seem to be involved in development and progression of glioblastoma and used as target therapies. Understanding the mechanisms in which those miRNAs are involved and their role in epigenetic pathways that lead to cancer, as well as their potential in clinical application, may improve GBM clinical outcome (CRD42020182706, 07/10/2020, retrospectively registered).
胶质母细胞瘤（GBM）是最常见、侵袭性最强且恶性程度最高的胶质瘤类型，尽管医学知识和技术不断进步，但其预后仍然很差。已知一些微小RNA（miRNA）可能失调并与肿瘤相关。我们旨在研究可能作为人类胶质母细胞瘤潜在生物标志物的miRNA。通过使用PubMed、LILACS和SCIELO数据库进行检索，以查找2015年至2020年与人类体外和体内数据相关的论文。从99篇文章中筛选出10篇符合条件的文章，并发现了13种失调的miRNA，同时对其调控、靶标、途径和机制进行了描述。发现了感兴趣的miRNA，它们似乎参与了胶质母细胞瘤的发生和发展，并可作为靶向治疗的靶点。了解这些miRNA所涉及的机制及其在导致癌症的表观遗传途径中的作用，以及它们在临床应用中的潜力，可能会改善GBM的临床结局（CRD42020182706，2020年10月7日，回顾性注册）。
