多发性骨髓瘤患者骨髓中 Dickkopf 相关蛋白 1 的表达：与骨病和浆细胞恶性程度的相关性。
Dickkopf-related protein 1 expression in bone marrow of multiple myeloma patients: correlation with bone disease and plasma cell malignancy type.
机构信息
Riga Stradiņš University, A. Kirchenstein Institute of Microbiology and Virology, Riga LV-1007, Latvia.
Riga East University Hospital, Oncology Center of Latvia, Riga LV-1079, Latvia.
出版信息
Exp Oncol. 2020 Dec;42(4):285-288. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-4.15289.
BACKGROUND
Previous studies have pointed out the role of dickkopf-related protein 1 (DKK 1) - Wnt inhibitor, which is essential for osteoblast functioning, in the development of osteolytic lesions in multiple myeloma (MM).
AIM
To assess the DKK 1 expression displayed by myeloma cells in bone marrow trephine biopsies of patients with and without osteolytic lesions, and in different malignancy grades of the disease.
METHODS
The expression level of DKK 1 was assessed immunohistochemically in bone marrow of 49 MM patients presented with and without osteolytic lesions (the 1 and the 2 group, respectively).
RESULTS
Levels of weak, moderate, and strong DKK 1 expression were distributed - as 43.33, 27.78 and 25.56%, and 63.91, 18.80, and 1.50%, respectively when evaluating the samples obtained from the 1 and the 2 group. Statistically significant differences were found when the levels of DKK 1 expression in the 1 and the 2 group were compared (χ = 51; df = 3; p < 0.001).
CONCLUSIONS
DKK 1 contributes to the development of osteolytic lesions in MM. The present study provides morphological evidence that inhibition in Wnt signaling may lead to bone damage observed in the advanced stage of the disease.
背景
先前的研究指出 Dickkopf 相关蛋白 1（DKK1）——一种对成骨细胞功能至关重要的 Wnt 抑制剂，在多发性骨髓瘤（MM）溶骨性病变的发展中起作用。
目的
评估有和无溶骨性病变的 MM 患者骨髓活检中骨髓瘤细胞的 DKK1 表达，并评估疾病不同恶性程度的 DKK1 表达。
方法
通过免疫组织化学方法评估 49 例 MM 患者骨髓中 DKK1 的表达水平，这些患者有和无溶骨性病变（分别为第 1 组和第 2 组）。
结果
在评估第 1 组和第 2 组获得的样本时，DKK1 表达的弱、中、强水平分别分布为 43.33%、27.78%和 25.56%，63.91%、18.80%和 1.50%。当比较第 1 组和第 2 组的 DKK1 表达水平时，发现有统计学显著差异（χ=51；df=3；p<0.001）。
结论
DKK1 有助于 MM 溶骨性病变的发展。本研究提供了形态学证据，表明 Wnt 信号抑制可能导致疾病晚期观察到的骨损伤。
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