Reproductive Health Research Center, Department of Obstetrics & Gynecology, Al-Zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Vice-Chancellorship of Research and Technology, Guilan University of Medical Science, Rasht, Iran.
Arch Iran Med. 2020 Dec 1;23(12):856-863. doi: 10.34172/aim.2020.114.
Due to the physiological changes in the body during pregnancy, the increased susceptibility to viral infections during this period and also the high prevalence of coronavirus disease 2019 (COVID-19) in the Guilan province, Iran, this study aimed to evaluate risk factors, clinical symptoms, laboratory findings and imaging of pregnant mothers with COVID-19.
In this descriptive study, 70 pregnant women aged 17-41 years with COVID-19 who were hospitalized from early March to late April 2020 were enrolled. Sampling was performed by census and from all hospitals in Guilan. The research instruments included a researcher-made questionnaire, including demographic characteristics, clinical symptoms, medical examinations, and paraclinical results. Data were analyzed with SPSS version 16. Frequency and percent were used to describe qualitative variables; for quantitative variables, if they were normally distributed, mean and standard deviation were used, and if they were non-normal, median and interquartile range (IQR) were used.
The most severe symptoms recorded in mothers at the time of hospitalization were fever (47%), shortness of breath (16%) and cough (15%), respectively. One of 68 (1%) was in the severe stage of the disease and two mothers (2%) were in critical condition and admitted to the intensive care unit and finally died. Fifty-five of 66 women (83%) had lymphopenia, 22 of 42 (52%) tested positive on PCR, and 30 of 33 (90%) had an increase in lactate dehydrogenase (LDH) levels.Results showed that 15 of 32 patients who gave birth had preterm delivery (46%).
The most common manifestations of the disease in pregnant women were fever, cough and shortness of breath, and in some cases muscle pain. The most common laboratory finding in infected mothers was lymphopenia. Complications of pregnancy and childbirth in women included an increase in cesarean delivery.
由于孕妇体内的生理变化，在此期间对病毒感染的易感性增加，以及伊朗吉兰省 2019 年冠状病毒病（COVID-19）的高流行率，本研究旨在评估患有 COVID-19 的孕妇的危险因素、临床症状、实验室检查结果和影像学表现。
在这项描述性研究中，纳入了 2020 年 3 月初至 4 月下旬期间因 COVID-19 住院的 70 名年龄在 17-41 岁的孕妇。通过普查和从吉兰省所有医院进行抽样。研究工具包括一份由研究人员制作的问卷，其中包括人口统计学特征、临床症状、体检和辅助检查结果。数据采用 SPSS 16 版进行分析。定性变量采用频率和百分比描述；对于定量变量，如果呈正态分布，则使用均数和标准差；如果呈非正态分布，则使用中位数和四分位间距（IQR）。
母亲住院时最严重的症状分别是发热（47%）、呼吸急促（16%）和咳嗽（15%）。68 例患者中有 1 例（1%）为疾病重度期，2 例（2%）为危重症患者，收入重症监护病房，最终死亡。66 例中有 55 例（83%）淋巴细胞减少，42 例中有 22 例（52%）PCR 阳性，33 例中有 30 例（90%）乳酸脱氢酶（LDH）水平升高。结果显示，32 名分娩的患者中有 15 名（46%）早产。
孕妇最常见的疾病表现为发热、咳嗽和呼吸急促，在某些情况下还伴有肌肉疼痛。感染母亲最常见的实验室发现是淋巴细胞减少。妇女妊娠和分娩的并发症包括剖宫产率增加。
