Institute for Global Health, University College London, London, UK.
Division of Infectious Diseases, Imperial College London, London, UK.
AIDS Care. 2021 Oct;33(10):1296-1307. doi: 10.1080/09540121.2020.1865518. Epub 2020 Dec 28.
We investigated the correlations and agreement between cognitive assessments made using a computerised (CogState™, six domains) and a standard pen-and-paper battery (five domains) in PWH and lifestyle-similar HIV-negative individuals. Demographically adjusted domain and global -scores were obtained and used to define cognitive impairment according to the multivariate normative comparison (MNC) criteria. Correlations between -scores and the agreement between the classifications of cognitive impairment obtained from the two batteries were assessed using the Spearman's rank correlation and Cohen's , respectively. The correlation between global -scores from the two batteries was 0.52 (95% CI 0.44-0.60) in PWH and 0.45 (0.29-0.59) in controls (=0.38 for their difference). Correlations were generally stronger between domains within the same battery than between those from different batteries. The agreement between the two batteries in classifying individuals as cognitively impaired or not impaired was fair in PWH (=0.24) and poor in HIV-negative individuals (=-0.02). The moderate correlation between overall cognitive function and the modest agreement between binary classifications of cognitive impairment obtained from two different batteries indicate the two batteries may assess slightly different components of cognition.
我们研究了使用计算机化（CogState™，六个领域）和标准纸笔电池（五个领域）对 PWH 和生活方式相似的 HIV 阴性个体进行认知评估之间的相关性和一致性。获得了经过人口统计学调整的域和总体评分，并根据多变量规范比较（MNC）标准定义认知障碍。使用 Spearman 秩相关和 Cohen's 分别评估 -评分之间的相关性和来自两种电池的认知障碍分类之间的一致性。在 PWH 中，两种电池的全球评分之间的相关性为 0.52（95%CI 0.44-0.60），在对照组中为 0.45（0.29-0.59）（差异为 0.38）。同一电池内的域之间的相关性通常强于不同电池之间的相关性。在 PWH 中，两种电池在将个体分类为认知受损或未受损方面的一致性为中等（=0.24），在 HIV 阴性个体中较差（=-0.02）。整体认知功能与来自两种不同电池的认知障碍二分法之间的适度一致性表明，两种电池可能评估认知的略有不同成分。
