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多模式疼痛管理方案用于桡骨远端骨折的开放性治疗:一项随机、盲法研究。

A Multimodal Pain Management Regimen for Open Treatment of Distal Radius Fractures: A Randomized Blinded Study.

机构信息

Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.

Rothman Orthopaedic Institute, Philadelphia, PA, USA.

出版信息

Hand (N Y). 2022 Nov;17(6):1187-1193. doi: 10.1177/1558944720975146. Epub 2020 Dec 24.

Abstract

BACKGROUND

Adequate pain control is critical after outpatient surgery where patients are not as closely monitored. A multimodal pain management regimen was compared to a conventional pain management method in patients undergoing operative fixation for distal radius fractures. We hypothesized that there would be a decrease in the amount of narcotics used by the multimodal group compared to the conventional pain management group, and that there would be no difference in bone healing postoperatively.

METHODS

Forty-two patients were randomized into 2 groups based on pain protocols. Group 1, the control, received a regional block, acetaminophen, and oxycodone. Group 2 received a multimodal pain regimen consisting of daily doses of pregabalin, celecoxib, and acetaminophen up until postoperative day (POD) #3. They also received a regional block with oxycodone for breakthrough pain.

RESULTS

From POD#3 to week 1, there was a significant increase in oxycodone use in the study group correlating with the point in time when the multimodal regimen was discontinued. The shortened Disabilities of the Arm, Shoulder, and Hand Questionnaire (QuickDASH) scores taken at 2 weeks postoperation showed a significantly lower average score in the study group compared to the control. There was no difference in bone healing.

CONCLUSIONS

The 2 regimens yielded similar pain control after surgery. The rebound increase in narcotic use after the multimodal regimen was discontinued, and significant difference in QuickDASH scores seen at 2 weeks postoperatively supported that multimodal regimens may not necessarily lead to decreased narcotic use in outpatient upper extremity surgery, but in the short term are shown to improve functional status.

摘要

背景

门诊手术后,患者的监测不如住院时那么密切,因此需要充分的疼痛控制。我们比较了多模式疼痛管理方案与传统疼痛管理方法在接受桡骨远端骨折手术固定的患者中的应用。我们假设多模式组与传统疼痛管理组相比,使用阿片类药物的量会减少,并且术后骨愈合没有差异。

方法

根据疼痛方案,将 42 名患者随机分为 2 组。第 1 组(对照组)接受区域阻滞、对乙酰氨基酚和羟考酮。第 2 组接受多模式疼痛管理方案,包括普瑞巴林、塞来昔布和对乙酰氨基酚的每日剂量,直至术后第 3 天(POD)。他们还接受了含羟考酮的区域阻滞以缓解爆发性疼痛。

结果

从 POD3 到第 1 周,研究组的羟考酮用量显著增加,与多模式方案停药的时间点相关。术后 2 周时的缩短版上肢残疾问卷(QuickDASH)评分显示,研究组的平均得分明显低于对照组。两组骨愈合情况无差异。

结论

两种方案在术后都能达到相似的疼痛控制效果。多模式方案停药后阿片类药物用量反弹增加,术后 2 周 QuickDASH 评分差异显著,这表明多模式方案不一定能减少门诊上肢手术中阿片类药物的使用,但在短期内能改善功能状态。

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