孕期使用合生制剂改善血糖状态的Meta 分析：随机临床试验研究
Synbiotic supplementation for glycemic status in pregnant women: a meta-analysis of randomized clinical trials.
机构信息
Department of Endocrinology, Quzhou People's Hospital, Quzhou, P. R. China.
出版信息
Gynecol Endocrinol. 2021 Feb;37(2):146-151. doi: 10.1080/09513590.2020.1853696. Epub 2020 Dec 28.
BACKGROUND
The effect of synbiotic supplementation on glycemic status in pregnant women remained controversial and this meta-analysis aimed to explore the efficacy of synbiotic supplementation on glycemic status in pregnant women.
METHODS
We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases and randomized controlled trials (RCTs) assessing the effect of synbiotic on glycemic status in pregnant women were included. The meta-analysis was performed using the random-effect model.
RESULTS
Four RCTs were included in the meta-analysis. Overall, compared with control intervention in pregnant women, synbiotic supplementation was associated with significantly reduced serum insulin (SMD = -0.69; 95%CI = -1.06 to -0.32; = .0002) and homoeostasis model assessment of insulin resistance (HOMA-IR, SMD = -0.53; 95%CI = -0.87 to -0.18; = .003), but had no significant effect on fasting plasma glucose (FPG, SMD = -0.16; 95%CI = -0.43 to 0.11; = .24), quantitative insulin sensitivity check index (QUICKI, SMD = 0.54; 95%CI = -0.10 to 1.18; = .10) or CRP (SMD = -0.29; 95%CI = -1.23 to 0.64; = .54).
CONCLUSIONS
Synbiotic supplementation was beneficial to glycemic control in pregnant women.
背景
共生元补充对孕妇血糖状况的影响仍存在争议，本荟萃分析旨在探讨共生元补充对孕妇血糖状况的疗效。
方法
我们检索了 PubMed、EMbase、Web of science、EBSCO 和 Cochrane 图书馆数据库，并纳入了评估共生元对孕妇血糖状况影响的随机对照试验（RCT）。荟萃分析采用随机效应模型进行。
结果
共有 4 项 RCT 纳入荟萃分析。总体而言，与孕妇的对照干预相比，共生元补充与血清胰岛素显著降低相关（SMD=-0.69；95%CI=-1.06 至-0.32； = .0002）和胰岛素抵抗稳态模型评估（HOMA-IR，SMD=-0.53；95%CI=-0.87 至-0.18； = .003），但对空腹血糖（FPG，SMD=-0.16；95%CI=-0.43 至 0.11； = .24）、定量胰岛素敏感性检查指数（QUICKI，SMD=0.54；95%CI=-0.10 至 1.18； = .10）或 C 反应蛋白（CRP，SMD=-0.29；95%CI=-1.23 至 0.64； = .54）无显著影响。
结论
共生元补充有益于孕妇的血糖控制。
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