Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.
Shanxi Key Laboratory of Material Strength & Structural Impact, Instisute of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.
J Biomater Sci Polym Ed. 2021 Apr;32(6):749-762. doi: 10.1080/09205063.2020.1866270. Epub 2021 Jan 11.
Open bone fractures in clinical are not only difficult to heal but also at a high risk of infections. Annual cases of fractures which result from osteoporosis amount to approximately 9 million. The objective of this study is to load the antibiotic drug of vancomycin and tune its controlled delivery on a bone repair scaffold material of Mineralized Collagen/poly(lactic acid) (MCP) changing the crystallinity of poly(lactic acid) to achieve inhibiting infection while repairing defects. We explored the crystallization process of the material during molding and prepared non-crystalline MCP1, MCP2, MCP3 and MCP4 by rapid freeze forming and crystalline MCP5 by tuning temperature decreasing rate. This method can control the micropore structure of the material; and the material changes from brittleness to toughness, which greatly enhances the control of mechanical properties. The drug release behavior of the material was studied for 28 days. Furthermore, the antibacterial property of the material was tested by the zone of inhibition, which shows the material good bacteriostasis. The controllable MCPs are expected to be substitutes for the treatment of infectious bone defects applying to clinical practical treatment.
临床开放性骨折不仅难以愈合，而且感染风险很高。每年因骨质疏松症导致的骨折病例约为 900 万例。本研究的目的是在矿化胶原/聚乳酸（MCP）骨修复支架材料上加载抗生素万古霉素，并调整其控制释放，改变聚乳酸的结晶度，从而在修复缺损的同时抑制感染。我们探索了材料在成型过程中的结晶过程，并通过快速冷冻成型制备了非晶态 MCP1、MCP2、MCP3 和 MCP4，通过调整降温速率制备了晶态 MCP5。该方法可以控制材料的微孔结构；并且材料从脆性变为韧性，这极大地增强了对机械性能的控制。研究了材料的药物释放行为 28 天。此外，通过抑菌圈试验测试了材料的抗菌性能，表明材料具有良好的抑菌作用。可控 MCP 有望替代治疗感染性骨缺损，适用于临床实际治疗。
