Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China.
Department of Neurology, The Second Clinical Medical College of Southern Medical University, Guangzhou, Guangdong, China.
Neurol Res. 2021 May;43(5):387-395. doi: 10.1080/01616412.2020.1866356. Epub 2020 Dec 23.
: We aimed to investigate factors related to in-hospital mortality (IHM) in acute ischemic stroke (AIS) patients.: We prospectively investigated 827,314 patients who were admitted within 7 days of AIS between August 2015 and July 2019. Demographic characteristics, risk factors, and clinical and laboratory characteristics of patients were assessed. Univariate and multivariate logistic regression analyses were performed to identify predictors associated with IHM.: The IHM rate in this study was 0.5% in women and 0.3% in men. Factors associated with IHM in AIS included diabetes (odds ratio [OR] 1.21, 95% confidence interval [CI] 1.03-1.43), female (OR 0.84, 95%CI 0.74-0.96), hypertension (OR 1.16, 95%CI 1.01-1.34), atrial fib/flutter (OR 1.51, 95%CI 1.29-1.77), other heart disease (OR1.43, 95%CI 1.23-1.67), prior myocardial infarction (OR 2.00, 95%CI 1.54-2.60), antiplatelet therapies (OR 0.71, 95%CI 0.60-0.84), gastrointestinal bleeding (OR 3.54, 95%CI 2.83-4.44), pulmonary embolism (OR 2.53, 95%CI1.41-4.53), dysphagia(OR7.32, 95%CI6.23-8.61), glycosylated hemoglobin (OR1.05, 95%CI 1.02-1.09), serum creatinine (OR 1.001, 95%CI 1.001-1.002), urea nitrogen (OR 1.10, 95%CI 1.08-1.12), National Institutes of Health Stroke Scale (NIHSS) score (4-5 vs. 0-4: OR 3.58; ≥15 vs. 0-4: OR 8.78), stroke rehabilitation (OR 0.27, 95%CI 0.23-0.30), age (third IQR vs. first IQR: OR 1.57; fourth IQR vs. first IQR: OR 2.23), and in-hospital stroke/TIArecurrence (OR 2.38, 95%CI 2.03-2.78).: The findings from this study may help clinicians control the risk of IHM better for patients with AIS.
: 目的：研究与急性缺血性脑卒中（AIS）患者院内死亡率（IHM）相关的因素。: 我们前瞻性调查了 2015 年 8 月至 2019 年 7 月 AIS 发病后 7 天内住院的 827314 例患者。评估了患者的人口统计学特征、危险因素以及临床和实验室特征。采用单因素和多因素逻辑回归分析来确定与 IHM 相关的预测因素。: 本研究中女性的 IHM 发生率为 0.5%，男性为 0.3%。与 AIS 相关的 IHM 因素包括糖尿病（比值比 [OR] 1.21，95%置信区间 [CI] 1.03-1.43）、女性（OR 0.84，95%CI 0.74-0.96）、高血压（OR 1.16，95%CI 1.01-1.34）、心房纤颤/扑动（OR 1.51，95%CI 1.29-1.77）、其他心脏病（OR1.43，95%CI 1.23-1.67）、既往心肌梗死（OR 2.00，95%CI 1.54-2.60）、抗血小板治疗（OR 0.71，95%CI 0.60-0.84）、胃肠道出血（OR 3.54，95%CI 2.83-4.44）、肺栓塞（OR 2.53，95%CI1.41-4.53）、吞咽困难（OR7.32，95%CI6.23-8.61）、糖化血红蛋白（OR1.05，95%CI 1.02-1.09）、血清肌酐（OR 1.001，95%CI 1.001-1.002）、尿素氮（OR 1.10，95%CI 1.08-1.12）、美国国立卫生研究院卒中量表（NIHSS）评分（4-5 分比 0-4 分：OR 3.58；≥15 分比 0-4 分：OR 8.78）、卒中康复（OR 0.27，95%CI 0.23-0.30）、年龄（第三四分位比第一四分位：OR 1.57；第四四分位比第一四分位：OR 2.23）以及住院期间卒中/TIA 复发（OR 2.38，95%CI 2.03-2.78）。: 本研究结果可能有助于临床医生更好地控制 AIS 患者的 IHM 风险。
