Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China 200233.
Dis Markers. 2021 Sep 30;2021:6103961. doi: 10.1155/2021/6103961. eCollection 2021.
Previous studies reported that the level of serum uric acid (SUA) was an important risk factor for acute cerebral infarction (ACI). However, the prognostic value of SUA levels in hospitalized patients with ACI has not been fully elucidated. The aim of this study was to investigate whether the SUA level on admission was associated with subsequent mortality in hospitalized patients with ACI.
The clinical data of ACI patients obtained from December 2017 to December 2019 were retrospectively reviewed. and Kaplan-Meier methods were used to compare the clinical differences and overall survival between patients with or without hyperuricemia, respectively. Univariate and multivariate analyses were used to identify independent prognoses.
In the total population, the in-hospital mortality of the hyperuricemia group was significantly higher than that of the normal uric acid group ( = 0.006). In the abnormal renal function group, the in-hospital mortality among the hyperuricemia group was significantly higher than the normal uric acid group ( = 0.002). However, there was no statistical difference of in-hospital mortality between the two groups in the normal renal function group ( = 0.321). Univariate and multivariate analyses showed that a previous history of diabetes ( = 0.018), hyperuricemia ( = 0.001), and National Institutes of Health Stroke Scale (NIHSS) score on admission ( ≤ 0.001) were independent factors for all samples. The hyperuricemia ( = 0.003) on admission were independent factors for patients with abnormal renal function.
In ACI patients with abnormal renal function, hyperuricemia may be associated with higher in-hospital mortality than patients with normal uric acid, and hyperuricemia may be an independent associated factor for in-hospital death in the subgroup patients.
先前的研究表明，血清尿酸（SUA）水平是急性脑梗死（ACI）的一个重要危险因素。然而，SUA 水平在住院 ACI 患者中的预后价值尚未得到充分阐明。本研究旨在探讨入院时的 SUA 水平是否与住院 ACI 患者的后续死亡率相关。
回顾性分析 2017 年 12 月至 2019 年 12 月住院 ACI 患者的临床资料，并分别采用 Kaplan-Meier 方法比较高尿酸血症组与正常尿酸组之间的临床差异和总生存情况。采用单因素和多因素分析确定独立预后因素。
在总人群中，高尿酸血症组的住院死亡率明显高于正常尿酸组（ = 0.006）。在异常肾功能组中，高尿酸血症组的住院死亡率明显高于正常尿酸组（ = 0.002）。然而，在正常肾功能组中，两组的住院死亡率无统计学差异（ = 0.321）。单因素和多因素分析显示，既往糖尿病史（ = 0.018）、高尿酸血症（ = 0.001）和入院时的美国国立卫生研究院卒中量表（NIHSS）评分（ ≤ 0.001）是所有样本的独立因素。入院时的高尿酸血症（ = 0.003）是肾功能异常患者的独立因素。
在肾功能异常的 ACI 患者中，高尿酸血症可能与较高的住院死亡率相关，而高尿酸血症可能是该亚组患者住院死亡的独立相关因素。
