Department of Vascular Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Vascular. 2021 Dec;29(6):913-919. doi: 10.1177/1708538120982698. Epub 2020 Dec 26.
Peripheral arterial disease is one common vascular disease most caused by atherosclerosis. As with stroke and coronary heart disease, peripheral arterial disease is one clinical type of atherosclerotic cardiovascular disease with many unmeasured environmental and genetic components. MTHFR C677T polymorphism is associated with the increased risk of ischemic stroke and coronary heart disease. MTHFR C677T polymorphism is associated with decreasing enzyme activity and increasing homocysteine levels. Meta-analysis of studies had demonstrated an association between elevated plasma homocysteine levels and peripheral arterial disease. Elevated plasma homocysteine level is closely related to MTHFR C677T polymorphism. Recent studies had clarified the relationship of MTHFR C677T polymorphism and peripheral arterial disease. So we performed a meta-analysis to investigate the association between MTHFR C677T polymorphism and peripheral arterial disease.
We searched the database PubMed, Embase, and Cochrane Library for all English-language articles related to peripheral arterial disease and MTHFR C677T through 30 June 2020. Analysis results were shown by forest plot. Publication bias was estimated using funnel plot.
A total of 15 studies comprising 1929 patients with peripheral arterial disease and 2952 healthy controls were included in the meta-analysis. Significant associations between MTHFR C677T genetic polymorphism and peripheral arterial disease were found (OR = 1.31, 95% CI: 1.09-1.58, <0.01). But there was no significant association (poor OR = 1.11, 95% CI: 0.98-1.26, =0.11) between the T allele carrier and peripheral arterial disease.
Our meta-analysis suggested that MTHFR C677T genetic polymorphism TT genotype may be associated with increased peripheral arterial disease risk. But further studies with large sample sizes are needed to confirm our findings.
外周动脉疾病是一种常见的血管疾病，主要由动脉粥样硬化引起。与中风和冠心病一样，外周动脉疾病是动脉粥样硬化性心血管疾病的一种临床类型，其发生涉及许多未被测量的环境和遗传因素。MTHFR C677T 多态性与缺血性中风和冠心病的风险增加有关。MTHFR C677T 多态性与酶活性降低和同型半胱氨酸水平升高有关。研究的荟萃分析表明，血浆同型半胱氨酸水平升高与外周动脉疾病之间存在关联。血浆同型半胱氨酸水平升高与 MTHFR C677T 多态性密切相关。最近的研究已经阐明了 MTHFR C677T 多态性与外周动脉疾病之间的关系。因此，我们进行了一项荟萃分析，以研究 MTHFR C677T 多态性与外周动脉疾病之间的关系。
我们通过 3 月 30 日检索了数据库 PubMed、Embase 和 Cochrane Library 中所有与外周动脉疾病和 MTHFR C677T 相关的英文文章。分析结果以森林图表示。使用漏斗图估计发表偏倚。
共有 15 项研究纳入了 1929 例外周动脉疾病患者和 2952 例健康对照者，进行了荟萃分析。MTHFR C677T 遗传多态性与外周动脉疾病之间存在显著相关性（OR=1.31，95%CI：1.09-1.58，<0.01）。但是，T 等位基因携带者与外周动脉疾病之间无显著相关性（OR=1.11，95%CI：0.98-1.26，=0.11）。
本荟萃分析表明，MTHFR C677T 遗传多态性 TT 基因型可能与外周动脉疾病风险增加有关。但是，需要进一步进行更大样本量的研究来证实我们的发现。
