Center for Cardiovascular Diseases, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, No. 63 Huangtang Road, Meijiang District, Meizhou, China.
Guangdong Provincial Engineering and Technology Research Center for Molecular Diagnostics of Cardiovascular Diseases, Meizhou, China.
BMC Cardiovasc Disord. 2023 Jun 24;23(1):319. doi: 10.1186/s12872-023-03354-0.
Arteriosclerosis in multiple arteries has long been associated with heightened cardiovascular risk. Acetaldehyde dehydrogenase 2 (ALDH2) and methylenetetrahydrofolate reductase (MTHFR) play an important role in the pathogenesis of arteriosclerosis by participating in the oxidation and reduction reactions in vascular endothelial cells. The purpose was to investigate the relationship of ALDH2 and MTHFR gene polymorphisms with arteriosclerosis in multiple arteries.
410 patients with arteriosclerosis in single artery and 472 patients with arteriosclerosis in multiple arteries were included. The relationship between ALDH2 rs671 and MTHFR rs1801133 polymorphisms and arteriosclerosis in single artery and arteriosclerosis in multiple arteries was analyzed.
The proportion of ALDH2 rs671 A allele (35.6% vs. 30.9%, P = 0.038) and MTHFR rs1801133 T allele (32.6% vs. 27.1%, P = 0.012) in patients with arteriosclerosis in multiple arteries was significantly higher than that in arteriosclerosis in single artery, respectively. The proportion of history of alcohol consumption in patients with ALDH2 rs671 G/G genotype was higher than those in ALDH2 rs671 G/A genotype and A/A genotype (P < 0.001). The results of logistic regression analysis indicated that ALDH2 rs671 A/A genotype (A/A vs. G/G: OR 1.996, 95% CI: 1.258-3.166, P = 0.003) and MTHFR rs1801133 T/T genotype (T/T vs. C/C: OR 1.943, 95% CI: 1.179-3.203, P = 0.009) may be independent risk factors for arteriosclerosis in multiple arteries (adjusted for age, sex, smoking, drinking, hypertension, and diabetes).
ALDH2 rs671 A/A and MTHFR rs1801133 T/T genotypes may be independent risk factors for arteriosclerosis in multiple arteries.
多发性动脉粥样硬化与心血管风险升高长期相关。乙醛脱氢酶 2（ALDH2）和亚甲基四氢叶酸还原酶（MTHFR）通过参与血管内皮细胞的氧化还原反应，在动脉粥样硬化的发病机制中发挥重要作用。本研究旨在探讨 ALDH2 和 MTHFR 基因多态性与多发性动脉粥样硬化的关系。
纳入 410 例单支动脉粥样硬化患者和 472 例多支动脉粥样硬化患者。分析 ALDH2 rs671 和 MTHFR rs1801133 多态性与单支动脉粥样硬化和多支动脉粥样硬化的关系。
多支动脉粥样硬化患者 ALDH2 rs671 A 等位基因（35.6%比 30.9%，P=0.038）和 MTHFR rs1801133 T 等位基因（32.6%比 27.1%，P=0.012）的比例明显高于单支动脉粥样硬化患者。ALDH2 rs671 G/G 基因型患者的饮酒史比例高于 ALDH2 rs671 G/A 基因型和 A/A 基因型（P<0.001）。多因素 logistic 回归分析结果表明，ALDH2 rs671 A/A 基因型（A/A 比 G/G：OR=1.996，95%CI：1.258-3.166，P=0.003）和 MTHFR rs1801133 T/T 基因型（T/T 比 C/C：OR=1.943，95%CI：1.179-3.203，P=0.009）可能是多支动脉粥样硬化的独立危险因素（调整年龄、性别、吸烟、饮酒、高血压和糖尿病因素后）。
ALDH2 rs671 A/A 和 MTHFR rs1801133 T/T 基因型可能是多支动脉粥样硬化的独立危险因素。
