Department of Internal Medicine, Military Hospital, Tunis El Manar University, Tunis, Tunisia.
Curr Rheumatol Rev. 2021;17(3):312-317. doi: 10.2174/1573397116666201224105359.
C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are routinely used to assess disease activity in spondyloarthritis. New biomarkers have been reported, such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), CRP to albumin ratio (CAR), and albumin to fibrinogen ratio (AFR).
Our study aimed to assess these ratios in spondyloarthritis and to determine the relationship between these ratios and the disease activity.
We conducted a cross-sectional study, including patients with spondyloarthritis. The following ratios were calculated: PLR, NLR, AFR, and CAR. Pearson correlation analysis was carried out to test the correlation of the data. Receiver operating characteristic curves were evaluated for each ratio using ASDAS as the gold standard for disease activity.
Eighty-five patients were included. The sex ratio was 60 males to 25 females. The mean age was 42.58 ± 11.75 years. There was a positive correlation between the PLR and the following parameters: CAR, CRP, and ESR. A negative correlation was found between AFR and the following ratios: PLR, NLR, CRP, and ESR. The ASDAS correlated negatively with AFR and positively with both PLR and CAR. The cutoff values of CAR and PLR to distinguish patients with very high disease activity (ASDAS>3.5) were 0.442 and 173.64, respectively.
Given their good correlation with ESR and CRP, we suggest that PLR, CAR, and AFR can be used as potential indicators of inflammation in spondyloarthritis. The CAR and PLR are useful to identify patients with very high disease activity.
C 反应蛋白（CRP）和红细胞沉降率（ESR）常用于评估脊柱关节炎的疾病活动度。已经报道了一些新的生物标志物，如中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、CRP 与白蛋白比值（CAR）和白蛋白与纤维蛋白原比值（AFR）。
本研究旨在评估这些比值在脊柱关节炎中的作用，并确定这些比值与疾病活动度的关系。
我们进行了一项横断面研究，纳入了脊柱关节炎患者。计算了以下比值：PLR、NLR、AFR 和 CAR。采用 Pearson 相关分析检验数据的相关性。使用 ASDAS 作为疾病活动的金标准，对每个比值的接收者操作特征曲线进行评估。
共纳入 85 例患者，男 60 例，女 25 例。平均年龄为 42.58±11.75 岁。PLR 与 CAR、CRP 和 ESR 呈正相关。AFR 与 PLR、NLR、CRP 和 ESR 呈负相关。ASDAS 与 AFR 呈负相关，与 PLR 和 CAR 呈正相关。CAR 和 PLR 区分疾病活动度极高（ASDAS>3.5）患者的截断值分别为 0.442 和 173.64。
鉴于它们与 ESR 和 CRP 具有良好的相关性，我们认为 PLR、CAR 和 AFR 可作为脊柱关节炎炎症的潜在标志物。CAR 和 PLR 有助于识别疾病活动度极高的患者。
