Department of Rheumatology and Clinical Immunology, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Department of Rheumatology and Clinical Immunology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Clin Rheumatol. 2021 Nov;40(11):4685-4691. doi: 10.1007/s10067-021-05827-z. Epub 2021 Jun 23.
The novel inflammatory markers C-reactive protein to albumin ratio (CAR), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) were associated with the disease activity of many autoimmune diseases. The aim of this study was to evaluate the association of these new inflammatory indexes with relapsing polychondritis disease activity index (RPDAI).
The data of relapsing polychondritis (RP) patients hospitalized between 2004 and 2020 at Peking Union Medical College Hospital were collected. One of the exclusive criteria was that RP patients overlapped with other diseases. Another was the RP patients with incomplete data. A total of 170 RP patients and 170 healthy controls (HCs) were included. The association of new inflammatory makers with RPDAI was assessed by Spearman's correlation analysis.
Compared to HCs, the CAR, NLR, and PLR were significantly higher in RP patients (both p < 0.001). The CAR, NLR, PLR, erythrocyte sedimentation rate and neutrophil counts in peripheral blood positively correlated with RPDAI. Blood albumin, lymphocyte count, hemoglobin (Hb) negatively correlated with RPDAI. The association of CAR, NLR, and PLR with RPDAI was demonstrated by Spearman's correlation analysis.
The novel inflammatory markers CAR, NLR and PLR were associated with RPDAI. Key Points • This is the first research to explore the association of CAR, NLR, and PLR with disease activity in patients with RP • CAR, NLR, and PLR are positively correlated with RPDAI • CAR, NLR, and PLR might be the potential predictors of disease activity in RP.
新型炎症标志物 C 反应蛋白与白蛋白比值（CAR）、中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）与许多自身免疫性疾病的疾病活动度相关。本研究旨在评估这些新的炎症指标与复发性多软骨炎疾病活动指数（RPDAI）的相关性。
收集了 2004 年至 2020 年期间在北京协和医院住院的复发性多软骨炎（RP）患者的数据。排除标准之一是 RP 患者与其他疾病重叠。另一个是 RP 患者数据不完整。共纳入 170 例 RP 患者和 170 名健康对照者（HCs）。采用 Spearman 相关分析评估新型炎症标志物与 RPDAI 的相关性。
与 HCs 相比，RP 患者的 CAR、NLR 和 PLR 显著升高（均 p<0.001）。CAR、NLR、PLR、红细胞沉降率和外周血中性粒细胞计数与 RPDAI 呈正相关。血白蛋白、淋巴细胞计数、血红蛋白（Hb）与 RPDAI 呈负相关。Spearman 相关分析显示 CAR、NLR 和 PLR 与 RPDAI 相关。
新型炎症标志物 CAR、NLR 和 PLR 与 RPDAI 相关。关键点：这是首次研究 CAR、NLR 和 PLR 与 RP 患者疾病活动度的相关性。CAR、NLR 和 PLR 与 RPDAI 呈正相关。CAR、NLR 和 PLR 可能是 RP 疾病活动的潜在预测因子。
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