纹状体的起起落落：多巴胺偏向纹状体和基质的上状态平衡。
The Ups and Downs of the Striatum: Dopamine Biases Upstate Balance of Striosomes and Matrix.
机构信息
McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Neuron. 2020 Dec 23;108(6):1013-1015. doi: 10.1016/j.neuron.2020.11.025.
Prager et al. demonstrate an opposite regulation of activity in striosomes and matrix of the striatum. By a D1-receptor-linked L-VGCC-dependent mechanism, dopamine release can extend upstates in matrix D1-expressing direct pathway projection neurons (dSPNs) but shorten them in striosomal dSPNs.
普拉格等人证明了纹状体的纹状体和基质中的活动受到相反的调节。通过 D1 受体连接的 L-VGCC 依赖性机制，多巴胺释放可以延长基质 D1 表达的直接通路投射神经元 (dSPN) 的兴奋状态，但缩短纹状体 dSPN 的兴奋状态。
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