使用人诱导多能干细胞衍生的心肌细胞快速评估致心律失常潜力 - Suppr

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Rapid Assessment of Proarrhythmic Potential Using Human iPSC-Derived Cardiomyocytes.

作者信息

Geiger Robert M, Klein Michael G, Fatima Naheed, Goldstein Robert E, Krantz Mori J, Haigney Mark C, Flagg Thomas P

出版信息

JACC Clin Electrophysiol. 2020 Dec;6(14):1860-1862. doi: 10.1016/j.jacep.2020.08.034.

DOI:10.1016/j.jacep.2020.08.034

PMID:33357585

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7758727/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a2/7758727/39d9cecdb684/gr1_lrg.jpg

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Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19.羟氯喹治疗 COVID-19 住院患者的观察性研究。

N Engl J Med. 2020 Jun 18;382(25):2411-2418. doi: 10.1056/NEJMoa2012410. Epub 2020 May 7.

Potent Inhibition of hERG Channels by the Over-the-Counter Antidiarrheal Agent Loperamide.洛哌丁胺（一种非处方药抗腹泻药）对 hERG 通道的强效抑制作用。

JACC Clin Electrophysiol. 2016 Dec;2(7):784-789. doi: 10.1016/j.jacep.2016.07.008. Epub 2016 Sep 14.

Azithromycin Causes a Novel Proarrhythmic Syndrome.阿奇霉素会引发一种新型的心律失常综合征。

Circ Arrhythm Electrophysiol. 2017 Apr;10(4). doi: 10.1161/CIRCEP.115.003560.

Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.羟氯喹通过调节超极化激活电流If降低心率：新的电生理见解和治疗潜力。

Heart Rhythm. 2015 Oct;12(10):2186-94. doi: 10.1016/j.hrthm.2015.05.027. Epub 2015 May 27.

Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil.心电图上鉴别药物诱导的多通道阻滞：多非利特、奎尼丁、雷诺嗪和维拉帕米的随机研究。

Clin Pharmacol Ther. 2014 Nov;96(5):549-58. doi: 10.1038/clpt.2014.155. Epub 2014 Jul 23.

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