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Rapid Assessment of Proarrhythmic Potential Using Human iPSC-Derived Cardiomyocytes.

作者信息

Geiger Robert M, Klein Michael G, Fatima Naheed, Goldstein Robert E, Krantz Mori J, Haigney Mark C, Flagg Thomas P

出版信息

JACC Clin Electrophysiol. 2020 Dec;6(14):1860-1862. doi: 10.1016/j.jacep.2020.08.034.

DOI:10.1016/j.jacep.2020.08.034
PMID:33357585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7758727/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a2/7758727/39d9cecdb684/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a2/7758727/39d9cecdb684/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a2/7758727/39d9cecdb684/gr1_lrg.jpg

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本文引用的文献

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Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19.羟氯喹治疗 COVID-19 住院患者的观察性研究。
N Engl J Med. 2020 Jun 18;382(25):2411-2418. doi: 10.1056/NEJMoa2012410. Epub 2020 May 7.
2
Potent Inhibition of hERG Channels by the Over-the-Counter Antidiarrheal Agent Loperamide.洛哌丁胺（一种非处方药抗腹泻药）对 hERG 通道的强效抑制作用。
JACC Clin Electrophysiol. 2016 Dec;2(7):784-789. doi: 10.1016/j.jacep.2016.07.008. Epub 2016 Sep 14.
3
Azithromycin Causes a Novel Proarrhythmic Syndrome.阿奇霉素会引发一种新型的心律失常综合征。
基于核糖核蛋白的 CRISPR/Cas9 编辑人类诱导多能干细胞中单核苷酸以模拟 3 型长 QT 综合征（SCN5A）。
Stem Cell Rev Rep. 2023 Nov;19(8):2774-2789. doi: 10.1007/s12015-023-10602-5. Epub 2023 Aug 31.
4
A human stem cell-derived neuronal model of morphine exposure reflects brain dysregulation in opioid use disorder: Transcriptomic and epigenetic characterization of postmortem-derived iPSC neurons.一种源自人类干细胞的吗啡暴露神经元模型反映了阿片类药物使用障碍中的大脑调节异常：死后来源的诱导多能干细胞神经元的转录组学和表观遗传学特征
Front Psychiatry. 2023 Feb 16;14:1070556. doi: 10.3389/fpsyt.2023.1070556. eCollection 2023.
Circ Arrhythm Electrophysiol. 2017 Apr;10(4). doi: 10.1161/CIRCEP.115.003560.
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Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.羟氯喹通过调节超极化激活电流If降低心率：新的电生理见解和治疗潜力。
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Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil.心电图上鉴别药物诱导的多通道阻滞：多非利特、奎尼丁、雷诺嗪和维拉帕米的随机研究。
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