Department of Zoology and Animal Welfare, Faculty of Animal Science, University of Agriculture in Krakow, 30-059 Krakow, Poland.
Laboratory of Biochemistry Adaptation and Ontogenesis of Animals, Institute of Animal Biology NAAS, 79034 Lviv, Ukraine.
Poult Sci. 2021 Jan;100(1):366-371. doi: 10.1016/j.psj.2020.10.016. Epub 2020 Oct 13.
Hexavalent chromium (Cr(VI)) has carcinogenic, nephrotoxic, hepatotoxic, and neurotoxic effects. Exposure to Cr(VI) can also lead to hematological alterations and blood biochemical changes. The literature on Cr(VI) toxicity concerns mostly adult forms of vertebrates. In this study, an attempt was made to determine the effect on the developing chicken embryo of Cr(VI) in ovo administration. It was observed that chromium affected the hatchability of chicks in a dose-dependent manner. At a dose from 25 to 250 μg per egg, Cr(VI) resulted in a statistically significant reduction of hatchability. Chromium administrated at lower doses (1.56 and 2.5 μg per egg) caused a statistically insignificant increase of hatchability. However, chromium at a level of LD (15.6 μg per egg) or 1/10 LD (1.56 per egg) did not cause major changes in hematological parameters or plasma biochemical indices in newly hatched chicks. The same doses did not lead to any histopathological changes in the liver.
六价铬（Cr(VI)）具有致癌、肾毒性、肝毒性和神经毒性作用。接触六价铬还会导致血液学改变和血液生化变化。关于六价铬毒性的文献主要涉及脊椎动物的成年形式。在这项研究中，试图确定 Cr(VI)在鸡胚中的体内给药对发育中的鸡胚的影响。结果表明，铬以剂量依赖的方式影响小鸡的孵化率。在 25 至 250μg/枚蛋的剂量下，Cr(VI)导致孵化率显著降低。较低剂量（1.56 和 2.5μg/枚蛋）的铬导致孵化率略有增加，但无统计学意义。然而，在 LD（15.6μg/枚蛋）或 1/10 LD（1.56μg/枚蛋）水平的铬并未导致刚孵出的小鸡血液学参数或血浆生化指标发生重大变化。相同剂量也不会导致肝脏出现任何组织病理学变化。
