全生物基壳聚糖接枝聚苯并恶嗪膜的抗菌性能：释放材料的制备与性能。
Antibacterial performance of fully biobased chitosan-grafted-polybenzoxazine films: Elaboration and properties of released material.
机构信息
Materials Chemistry Laboratory, Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar, Uttar Pradesh, 201314, India; Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Teknikringen 58, 100 44 Stockholm, Sweden.
Materials Chemistry Laboratory, Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar, Uttar Pradesh, 201314, India.
出版信息
Carbohydr Polym. 2021 Feb 15;254:117296. doi: 10.1016/j.carbpol.2020.117296. Epub 2020 Oct 24.
A fully biobased benzoxazine monomer, V-fa (using vanillin and furfurylamine) was grafted onto chitosan (CS) at different weight ratios (CV) using "grafting to" benign Schiff base chemistry. Incorporation of V-fa onto CS increased the tensile strength and improved chemical resistance of the CS-graft-V-fa films. Reversible labile linkages, expansion of CS galleries and leaching out of phenolic species from biobased polymer films led to an improved antibacterial activity against Staphylococcus aureus, which is ∼125 times higher than the bare CS film, V-fa and oligomeric V-fa. The leached out species from films were analyzed extensively by NMR, FTIR, GPC, ABTS and HRMS analysis. Oxidative-stress seems to be responsible for antibacterial activity. Current work illustrates an attractive synthetic approach and the improved antibacterial performance of biobased CS-graft-poly(V-fa) films which may hold as a potential alternative for wound-healing and implant applications in future.
一种完全生物基苯并恶嗪单体 V-fa（使用香草醛和糠胺）通过“接枝到”良性席夫碱化学以不同的重量比（CV）接枝到壳聚糖（CS）上。V-fa 的掺入增加了 CS-graft-V-fa 薄膜的拉伸强度和耐化学性。可逆的不稳定键、CS 腔的膨胀以及生物基聚合物薄膜中酚类物质的浸出导致对金黄色葡萄球菌的抗菌活性提高，约比裸 CS 薄膜、V-fa 和低聚物 V-fa 高 125 倍。通过 NMR、FTIR、GPC、ABTS 和 HRMS 分析对从薄膜中浸出的物质进行了广泛的分析。氧化应激似乎是抗菌活性的原因。目前的工作说明了一种有吸引力的合成方法和生物基 CS-graft-poly(V-fa)薄膜的改进的抗菌性能，这可能在未来作为伤口愈合和植入物应用的潜在替代品。
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