J Am Dent Assoc. 2021 Feb;152(2):105-114. doi: 10.1016/j.adaj.2020.09.021. Epub 2020 Dec 24.
The authors of this study aimed to evaluate the clinical antiplaque and antigingivitis effects of 3 oral hygiene regimens: toothbrushing with standard fluoride toothpaste and manual toothbrush and using a mouthrinse containing cetylpyridinium chloride, zinc lactate, and fluoride (CPC + Zn + F) in an alcohol-free base; toothbrushing with standard fluoride toothpaste and manual toothbrush and using a mouthrinse containing essential oils (EO) in an alcohol-free base; and toothbrushing with manual toothbrush and standard fluoride toothpaste and manual toothbrush (control).
The participants (N = 120) were randomly assigned to study groups and followed the assigned regimens twice daily for 6 weeks. The participants were examined by a calibrated examiner for the Quigley-Hein plaque index (Turesky modification) and Löe-Silness gingival index at baseline, week 4, and week 6. Statistical analyses were performed separately for plaque and gingival indexes by means of analysis of variance, paired t test, and analysis of covariance (α = 0.05).
At week 4, the CPC + Zn + F group presented additional reductions in dental plaque compared with EO and control groups of (21.4% [P < .001] and 31.4% [P < .001], respectively). After 6 weeks, these values were 26.7% (P < .001) and 44.8% (P < .001), respectively. For Löe-Silness gingival index, additional reduction in the CPC + Zn + F group compared with EO were 10.6% (P < .001) and 13.7% (P < .001) at 4 and 6 weeks, respectively. Compared with control, these reductions were 13.6% (P < .001) and 17.8% (P < .001), respectively.
The regimen including a mouthrinse containing CPC + Zn + F presented higher antiplaque and antigingivitis effects than EO and control regimens.
A mouthrinse containing CPC + Zn + F is an effective protocol for the control of dental plaque and gingivitis.
本研究的作者旨在评估三种口腔卫生方案的临床抗菌斑和抗牙龈炎效果：使用含氟标准牙膏和手动牙刷刷牙，以及使用不含酒精的含氯化十六烷基吡啶、乳酸锌和氟化物（CPC+Zn+F）的漱口液；使用不含酒精的含精油（EO）的含氟标准牙膏和手动牙刷刷牙；以及使用手动牙刷和标准含氟牙膏和手动牙刷（对照组）刷牙。
参与者（N=120）被随机分配到研究组，并按照指定方案每天刷牙两次，持续 6 周。在基线、第 4 周和第 6 周，由经过校准的检查者使用改良的 Quigley-Hein 菌斑指数（Turesky 改良法）和 Löe-Silness 牙龈指数对参与者进行检查。使用方差分析、配对 t 检验和协方差分析（α=0.05）分别对菌斑和牙龈指数进行统计分析。
第 4 周时，CPC+Zn+F 组与 EO 组和对照组相比，牙菌斑的减少分别为 21.4%（P<0.001）和 31.4%（P<0.001）。6 周后，这些值分别为 26.7%（P<0.001）和 44.8%（P<0.001）。对于 Löe-Silness 牙龈指数，与 EO 组相比，CPC+Zn+F 组在第 4 周和第 6 周的减少分别为 10.6%（P<0.001）和 13.7%（P<0.001）。与对照组相比，这些减少分别为 13.6%（P<0.001）和 17.8%（P<0.001）。
含 CPC+Zn+F 的漱口水方案比 EO 和对照组方案具有更高的抗菌斑和抗牙龈炎效果。
含 CPC+Zn+F 的漱口水是控制牙菌斑和牙龈炎的有效方案。
